Literature DB >> 24660822

Stereocontrolled total synthesis of hedyotol A.

Yusuke Kawabe1, Ryo Ishikawa, Yusuke Akao, Atsushi Yoshida, Makoto Inai, Tomohiro Asakawa, Yoshitaka Hamashima, Toshiyuki Kan.   

Abstract

The total synthesis of hedyotol A (1), a natural product isolated from Hedyotis lawsoniae (DC.) Wight et Arn. (Rubiaceae), was accomplished in a highly stereocontrolled manner. Key steps include an L-proline-catalyzed cross-aldol reaction and the biomimetic construction of a furofuran lignan skeleton through a quinomethide intermediate.

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Year:  2014        PMID： 24660822     DOI： 10.1021/ol500524y

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  3 in total

1.  Identification of a Novel TRPM8 Agonist from Nutmeg: A Promising Cooling Compound.

Authors:  Tomohiro Shirai; Kentaro Kumihashi; Mitsuyoshi Sakasai; Hiroshi Kusuoku; Yusuke Shibuya; Atsushi Ohuchi
Journal:  ACS Med Chem Lett       Date:  2017-05-31       Impact factor: 4.345

Review 2.  Lignans as Pharmacological Agents in Disorders Related to Oxidative Stress and Inflammation: Chemical Synthesis Approaches and Biological Activities.

Authors:  Dmitry I Osmakov; Aleksandr P Kalinovskii; Olga A Belozerova; Yaroslav A Andreev; Sergey A Kozlov
Journal:  Int J Mol Sci       Date:  2022-05-27       Impact factor: 6.208

3.  A sterically encumbered photoredox catalyst enables the unified synthesis of the classical lignan family of natural products.

Authors:  Edwin Alfonzo; Aaron B Beeler
Journal:  Chem Sci       Date:  2019-07-05       Impact factor: 9.825
  3 in total

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