OBJECTIVE: The relationship between morphologic alterations of pulmonary small vessels and pulmonary perfusion has not been clarified. The purpose of this study was to evaluate the relationship between the cross-sectional area (CSA) of pulmonary small vessels alterations measured on CT images and pulmonary perfusion on lung perfusion scintigraphy. MATERIALS AND METHODS: This study comprised 46 subjects who underwent both CT and lung perfusion scintigraphy. We measured CSA of pulmonary small vessels less than 5 mm(2) and 5-10 mm(2) using CT images and obtained the percentage of the right lung to whole lung in each CSA group (CSA<5,R/W and CSA5-10,R/W, respectively). Using (99m)Tc-macroaggregated albumin (MAA) lung perfusion scintigraphy, we obtained right and total lung counts and calculated the percentage of the right to whole-lung counts (MAAR/W). Those CT and scintigraphy measurements were also calculated separately each in right upper, right lower, left upper, and left lower zones. The correlations of CSA<5,R/W and CSA5-10,R/W with MAAR/W, the correlation between the percentage of each lung zone to whole-lung CSA<5 and the percentage of each corresponding lung zone to whole-lung MAA were evaluated. RESULTS: The mean CSA<5,R/W was 58.1% ± 11.2%, and the mean MAAR/W was 59.3% ± 17.9%. CSA<5,R/W had a significant correlation with MAAR/W (ρ = 0.865, p < 0.0001), whereas significant correlation was found but was relatively weak between CSA5-10,R/W and MAAR/W (ρ = 0.512, p = 0.0003). The percentage of each lung zone to whole-lung CSA<5 had significant correlations with the percentage of each corresponding lung zone to whole-lung MAA. CONCLUSION: Pulmonary small vessels alteration, as measured by CSA on CT images, significantly correlated with pulmonary perfusion.
OBJECTIVE: The relationship between morphologic alterations of pulmonary small vessels and pulmonary perfusion has not been clarified. The purpose of this study was to evaluate the relationship between the cross-sectional area (CSA) of pulmonary small vessels alterations measured on CT images and pulmonary perfusion on lung perfusion scintigraphy. MATERIALS AND METHODS: This study comprised 46 subjects who underwent both CT and lung perfusion scintigraphy. We measured CSA of pulmonary small vessels less than 5 mm(2) and 5-10 mm(2) using CT images and obtained the percentage of the right lung to whole lung in each CSA group (CSA<5,R/W and CSA5-10,R/W, respectively). Using (99m)Tc-macroaggregated albumin (MAA) lung perfusion scintigraphy, we obtained right and total lung counts and calculated the percentage of the right to whole-lung counts (MAAR/W). Those CT and scintigraphy measurements were also calculated separately each in right upper, right lower, left upper, and left lower zones. The correlations of CSA<5,R/W and CSA5-10,R/W with MAAR/W, the correlation between the percentage of each lung zone to whole-lung CSA<5 and the percentage of each corresponding lung zone to whole-lung MAA were evaluated. RESULTS: The mean CSA<5,R/W was 58.1% ± 11.2%, and the mean MAAR/W was 59.3% ± 17.9%. CSA<5,R/W had a significant correlation with MAAR/W (ρ = 0.865, p < 0.0001), whereas significant correlation was found but was relatively weak between CSA5-10,R/W and MAAR/W (ρ = 0.512, p = 0.0003). The percentage of each lung zone to whole-lung CSA<5 had significant correlations with the percentage of each corresponding lung zone to whole-lung MAA. CONCLUSION: Pulmonary small vessels alteration, as measured by CSA on CT images, significantly correlated with pulmonary perfusion.
Authors: Andrew J Synn; Chunyi Zhang; George R Washko; Raúl San José Estépar; George T O'Connor; Wenyuan Li; Murray A Mittleman; Mary B Rice Journal: Ann Am Thorac Soc Date: 2019-06
Authors: Farbod N Rahaghi; Carolyn E Come; James Ross; Rola Harmouche; Alejandro A Diaz; Raul San Jose Estepar; George Washko Journal: Chronic Obstr Pulm Dis Date: 2015
Authors: Carrie L Pistenmaa; P Nardelli; S Y Ash; C E Come; A A Diaz; F N Rahaghi; R G Barr; K A Young; G L Kinney; J P Simmons; R C Wade; J M Wells; J E Hokanson; G R Washko; R San José Estépar Journal: Chest Date: 2021-02-16 Impact factor: 10.262