Literature DB >> 24660047

Pragmatic Language in autism and fragile X syndrome: Genetic and clinical applications.

Molly Losh1, Gary E Martin2, Jessica Klusek2, Abigail L Hogan-Brown1.   

Abstract

Evidence suggests a strong genetic basis to autism. Our research program focuses on identifying genetically meaningful phenotypes in autism, through family-genetic and cross-population methods, with a particular focus on language and social phenotypes that have been shown to aggregate in families of individuals with autism. In this article, we discuss recent findings from family study research implicating particular language and personality features as markers for genetic liability to autism and fragile X syndrome and FMR1-related variation in relatives. We conclude with consideration of the clinical implications of such findings.

Entities:  

Keywords:  Autism; Broad Autism Phenotype; FMR1 Premutation; Fragile X Syndrome; Pragmatic Language

Year:  2012        PMID： 24660047      PMCID： PMC3961489          DOI： 10.1044/lle19.2.48

Source DB:  PubMed          Journal:  Perspect Lang Learn Educ        ISSN： 1940-7742


  55 in total

1.  Personality and language characteristics in parents from multiple-incidence autism families.

Authors:  J Piven; P Palmer; R Landa; S Santangelo; D Jacobi; D Childress
Journal:  Am J Med Genet       Date:  1997-07-25

2.  Social language use in parents of autistic individuals.

Authors:  R Landa; J Piven; M M Wzorek; J O Gayle; G A Chase; S E Folstein
Journal:  Psychol Med       Date:  1992-02       Impact factor: 7.723

3.  The fragile X prevalence paradox.

Authors:  Paul J Hagerman
Journal:  J Med Genet       Date:  2008-04-15       Impact factor: 6.318

4.  Autism spectrum disorders and attention-deficit/hyperactivity disorder in boys with the fragile X premutation.

Authors:  Faraz Farzin; Hazel Perry; David Hessl; Danuta Loesch; Jonathan Cohen; Susan Bacalman; Louise Gane; Flora Tassone; Paul Hagerman; Randi Hagerman
Journal:  J Dev Behav Pediatr       Date:  2006-04       Impact factor: 2.225

5.  Clinical involvement and protein expression in individuals with the FMR1 premutation.

Authors:  F Tassone; R J Hagerman; A K Taylor; J B Mills; S W Harris; L W Gane; P J Hagerman
Journal:  Am J Med Genet       Date:  2000-03-13

6.  Defining genetically meaningful language and personality traits in relatives of individuals with fragile X syndrome and relatives of individuals with autism.

Authors:  Molly Losh; Jessica Klusek; Gary E Martin; John Sideris; Morgan Parlier; Joseph Piven
Journal:  Am J Med Genet B Neuropsychiatr Genet       Date:  2012-06-12       Impact factor: 3.568

Review 7.  The fragile-X premutation: a maturing perspective.

Authors:  Paul J Hagerman; Randi J Hagerman
Journal:  Am J Hum Genet       Date:  2004-03-29       Impact factor: 11.025

Review 8.  Lessons from fragile X regarding neurobiology, autism, and neurodegeneration.

Authors:  Randi J Hagerman
Journal:  J Dev Behav Pediatr       Date:  2006-02       Impact factor: 2.225

Review 9.  Autism genetics: strategies, challenges, and opportunities.

Authors:  Brian J O'Roak; Matthew W State
Journal:  Autism Res       Date:  2008-02       Impact factor: 5.216

Review 10.  Autistic phenotypes and genetic testing: state-of-the-art for the clinical geneticist.

Authors:  C Lintas; A M Persico
Journal:  J Med Genet       Date:  2008-08-26       Impact factor: 6.318
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  9 in total

1.  A Duck Wearing Boots?! Pragmatic Language Strategies for Repairing Communication Breakdowns Across Genetically Based Neurodevelopmental Disabilities.

Authors:  Jamie Barstein; Gary E Martin; Michelle Lee; Molly Losh
Journal:  J Speech Lang Hear Res       Date:  2018-06-19       Impact factor: 2.297

2.  Neural Processing of Speech Sounds in ASD and First-Degree Relatives.

Authors:  Shivani P Patel; Molly Winston; Janna Guilfoyle; Trent Nicol; Gary E Martin; Kritika Nayar; Nina Kraus; Molly Losh
Journal:  J Autism Dev Disord       Date:  2022-06-07

3.  Childhood Academic Performance: A Potential Marker of Genetic Liability to Autism.

Authors:  Janna Guilfoyle; Molly Winston; John Sideris; Gary E Martin; Kritika Nayar; Lauren Bush; Tom Wassink; Molly Losh
Journal:  J Autism Dev Disord       Date:  2022-02-23

4.  Brief Report: Linguistic Mazes and Perseverations in School-Age Boys with Fragile X Syndrome and Autism Spectrum Disorder and Relationships with Maternal Maze Use.

Authors:  Nell Maltman; Laura Friedman; Emily Lorang; Audra Sterling
Journal:  J Autism Dev Disord       Date:  2021-03-25

5.  The fragile X syndrome-autism comorbidity: what do we really know?

Authors:  Leonard Abbeduto; Andrea McDuffie; Angela John Thurman
Journal:  Front Genet       Date:  2014-10-16       Impact factor: 4.599

Review 6.  Fragile X Premutation: Medications, Therapy and Lifestyle Advice.

Authors:  Deepika Kour Sodhi; Randi Hagerman
Journal:  Pharmgenomics Pers Med       Date:  2021-12-29

7.  A Longitudinal Study of Parent-Child Interactions and Language Outcomes in Fragile X Syndrome and Other Neurodevelopmental Disorders.

Authors:  Lauren Bush; Gary E Martin; Emily Landau; Molly Losh
Journal:  Front Psychiatry       Date:  2021-11-08       Impact factor: 5.435

8.  Social communication in fragile X syndrome: pilot examination of the Brief Observation of Social Communication Change (BOSCC).

Authors:  Lucienne Ronco; Diego Cadavid; Rebecca Shaffer; Angela John Thurman; Shane Raines; So Hyun Kim
Journal:  J Neurodev Disord       Date:  2022-01-08       Impact factor: 4.025

9.  Links between looking and speaking in autism and first-degree relatives: insights into the expression of genetic liability to autism.

Authors:  Kritika Nayar; Peter C Gordon; Gary E Martin; Abigail L Hogan; Chelsea La Valle; Walker McKinney; Michelle Lee; Elizabeth S Norton; Molly Losh
Journal:  Mol Autism       Date:  2018-10-10       Impact factor: 7.509
  9 in total

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