Literature DB >> 24660025

Tracking and treating activated T cells.

N H Kim1, V Nadithe1, M Elsayed1, O M Merkel2.   

Abstract

Upon activation, T cells of various subsets are the most important mediators in cell-mediated immune responses. Activated T cells play an important role in immune system related diseases such as chronic inflammatory diseases, viral infections, autoimmune disease, transplant rejection, Crohn disease, diabetes, and many more. Therefore, efforts have been made to both visualize and treat activated T cells specifically. This review summarizes imaging approaches and selective therapeutics for activated T cells and gives an outlook on how tracking and treating can be combined into theragnositc agents for activated T cells.

Entities:  

Keywords:  Activated T cells; Imaging; Targeting; Theragnostics; Treatment; siRNA

Year:  2013        PMID： 24660025      PMCID： PMC3959737          DOI： 10.1016/s1773-2247(13)50002-5

Source DB:  PubMed          Journal:  J Drug Deliv Sci Technol        ISSN： 1773-2247            Impact factor:   3.981


  66 in total

1.  Targeting of active mTOR inhibits primary leukemia T cells and synergizes with cytotoxic drugs and signaling inhibitors.

Authors:  Ana Batista; João T Barata; Elke Raderschall; Stephen E Sallan; Nadia Carlesso; Lee M Nadler; Angelo A Cardoso
Journal:  Exp Hematol       Date:  2011-01-26       Impact factor: 3.084

2.  T cell-specific siRNA delivery using antibody-conjugated chitosan nanoparticles.

Authors:  Jangwook Lee; Kyoung-Soo Yun; Chang Seon Choi; Seung-Hwa Shin; Hong-Seok Ban; Taiyoun Rhim; Sang Kyung Lee; Kuen Yong Lee
Journal:  Bioconjug Chem       Date:  2012-05-31       Impact factor: 4.774

Review 3.  NFAT proteins: key regulators of T-cell development and function.

Authors:  Fernando Macian
Journal:  Nat Rev Immunol       Date:  2005-06       Impact factor: 53.106

Review 4.  Regulation of T-cell activation by the cytoskeleton.

Authors:  Daniel D Billadeau; Jeffrey C Nolz; Timothy S Gomez
Journal:  Nat Rev Immunol       Date:  2007-02       Impact factor: 53.106

5.  Mitochondria-dependent apoptosis of activated T lymphocytes induced by astin C, a plant cyclopeptide, for preventing murine experimental colitis.

Authors:  Yan Shen; Qiong Luo; Huimin Xu; Fangyuan Gong; Xiaobin Zhou; Yang Sun; Xuefeng Wu; Wen Liu; Guangzhi Zeng; Ninghua Tan; Qiang Xu
Journal:  Biochem Pharmacol       Date:  2011-05-05       Impact factor: 5.858

6.  Clinical, biological, and endoscopic picture of attacks of Crohn's disease. Evolution on prednisolone. Groupe d'Etude Thérapeutique des Affections Inflammatoires Digestives.

Authors:  R Modigliani; J Y Mary; J F Simon; A Cortot; J C Soule; J P Gendre; E Rene
Journal:  Gastroenterology       Date:  1990-04       Impact factor: 22.682

Review 7.  Immunology of asthma and chronic obstructive pulmonary disease.

Authors:  Peter J Barnes
Journal:  Nat Rev Immunol       Date:  2008-02-15       Impact factor: 53.106

8.  Analysis of activated T cell infiltrates in rat renal allografts by gamma camera imaging after injection of 123iodine-interleukin 2.

Authors:  I C Abbs; J R Pratt; M J Dallman; S H Sacks
Journal:  Transpl Immunol       Date:  1993       Impact factor: 1.708

9.  Selective triggering of apoptosis of concanavalin A-activated T cells by fraxinellone for the treatment of T-cell-dependent hepatitis in mice.

Authors:  Yang Sun; Yu Qin; Fang-Yuan Gong; Xue-Feng Wu; Zi-Chun Hua; Ting Chen; Qiang Xu
Journal:  Biochem Pharmacol       Date:  2009-03-14       Impact factor: 5.858

10.  Synthesis and optimization of the labeling procedure of 99mTc-HYNIC-interleukin-2 for in vivo imaging of activated T lymphocytes.

Authors:  Calogero D'Alessandria; Valentina di Gialleonardo; Marco Chianelli; Stephen J Mather; Erik F J de Vries; Francesco Scopinaro; Rudi A Dierck; Alberto Signore
Journal:  Mol Imaging Biol       Date:  2009-12-01       Impact factor: 3.488
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  7 in total

1.  Evaluating the Regulation of Cytokine Levels After siRNA Treatment in Antigen-Specific Target Cell Populations via Intracellular Staining.

Authors:  Rima Kandil; Daniel Feldmann; Yuran Xie; Olivia M Merkel
Journal:  Methods Mol Biol       Date:  2019

Review 2.  siRNA delivery to the lung: what's new?

Authors:  Olivia M Merkel; Israel Rubinstein; Thomas Kissel
Journal:  Adv Drug Deliv Rev       Date:  2014-06-05       Impact factor: 15.470

Review 3.  T-cell targeted pulmonary siRNA delivery for the treatment of asthma.

Authors:  Tobias W M Keil; Domizia Baldassi; Olivia M Merkel
Journal:  Wiley Interdiscip Rev Nanomed Nanobiotechnol       Date:  2020-04-08

4.  Removal of Fc Glycans from [89Zr]Zr-DFO-Anti-CD8 Prevents Peripheral Depletion of CD8+ T Cells.

Authors:  Jordan M White; Outi M Keinänen; Brendon E Cook; Brian M Zeglis; Heather M Gibson; Nerissa T Viola
Journal:  Mol Pharm       Date:  2020-05-12       Impact factor: 4.939

Review 5.  Pulmonary Delivery of siRNA via Polymeric Vectors as Therapies of Asthma.

Authors:  Yuran Xie; Olivia M Merkel
Journal:  Arch Pharm (Weinheim)       Date:  2015-07-07       Impact factor: 3.751

6.  Coming in and Finding Out: Blending Receptor-Targeted Delivery and Efficient Endosomal Escape in a Novel Bio-Responsive siRNA Delivery System for Gene Knockdown in Pulmonary T Cells.

Authors:  Rima Kandil; Yuran Xie; Ralf Heermann; Lorenz Isert; Kirsten Jung; Aditi Mehta; Olivia M Merkel
Journal:  Adv Ther (Weinh)       Date:  2019-04-26

7.  Targeted delivery of siRNA to activated T cells via transferrin-polyethylenimine (Tf-PEI) as a potential therapy of asthma.

Authors:  Yuran Xie; Na Hyung Kim; Venkatareddy Nadithe; Dana Schalk; Archana Thakur; Ayşe Kılıç; Lawrence G Lum; David J P Bassett; Olivia M Merkel
Journal:  J Control Release       Date:  2016-03-19       Impact factor: 9.776
  7 in total

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