Hai-Jun Yan1, Yan Tan, Wei Gu. 1. Department of Respiratory Medicine, Affiliatted Nanjing hospital, Nanjing Medical University, Jiangsu Province, P.R. China.
Abstract
PURPOSE: The predictive and prognostic role of neuron-specific enolase (NSE) in non-small cell lung cancer (NSCLC) is still under debate. The present meta-analysis aimed to evaluate the relation between serum NSE levels and the prognosis of NSCLC. METHODS: We performed a meta-analysis of published studies assessing the association of NSE with the prognosis of NSCLC. Literature retrieval, trials' selection and assessment, data collection, and statistical analysis were performed according to the Revman 5.0 guidelines. A fixed-effect model was used to pool the hazard ratio (HR) and 95% confidence intervals (95% CIs). RESULTS: A total of 8 eligible studies that included 2389 NSCLC patients were analyzed. We did not find prognostic value of NSE for NSCLC (HR=1.17, 95% CI: 0.95-1.44, p=0.14). CONCLUSION: The present study indicated that serum NSE level is of no prognostic significance in patients with NSCLC.
PURPOSE: The predictive and prognostic role of neuron-specific enolase (NSE) in non-small cell lung cancer (NSCLC) is still under debate. The present meta-analysis aimed to evaluate the relation between serum NSE levels and the prognosis of NSCLC. METHODS: We performed a meta-analysis of published studies assessing the association of NSE with the prognosis of NSCLC. Literature retrieval, trials' selection and assessment, data collection, and statistical analysis were performed according to the Revman 5.0 guidelines. A fixed-effect model was used to pool the hazard ratio (HR) and 95% confidence intervals (95% CIs). RESULTS: A total of 8 eligible studies that included 2389 NSCLCpatients were analyzed. We did not find prognostic value of NSE for NSCLC (HR=1.17, 95% CI: 0.95-1.44, p=0.14). CONCLUSION: The present study indicated that serum NSE level is of no prognostic significance in patients with NSCLC.
Authors: M G Dal Bello; R A Filiberti; A Alama; A M Orengo; M Mussap; S Coco; I Vanni; S Boccardo; E Rijavec; C Genova; F Biello; G Barletta; G Rossi; M Tagliamento; C Maggioni; F Grossi Journal: J Transl Med Date: 2019-03-08 Impact factor: 5.531