Abdel-Raheim M A Meki1, Hani Al-Shobaili. 1. Department of Medical Biochemistry, College of Medicine, Qassim University, Almlaida, Kingdom of Saudi Arabia.
Abstract
BACKGROUND: Vascular endothelial growth factor (VEGF), transforming growth factor β1 (TGF-β1), and nitric oxide (NO) have been reported to be contributory factors to the pathogenesis of psoriasis vulgaris. In the current study, we aimed to investigate the association between the levels of VEGF, TGF-β1, and NO and psoriasis severity (as expressed by psoriasis area severity index, PASI). METHODS: Fifty-eight patients with psoriasis vulgaris and twenty-two controls were included in the study. The serum levels of VEGF and TGF-β1 were estimated by ELISA technique. The serum levels of NO were determined by colorimetric method. RESULTS: The serum levels of VEGF, TGF-β1, and NO were significantly higher in patients than controls. Moreover, the serum levels of the studied biochemical variables in patients with severe disease activity were significantly higher than mild cases. The duration of disease showed significant positive correlations with each VEGF (r = 0.35, P < 0.01) and TGF-β1 (r = 0.41, P < 0.05). In addition, the PASI score was significantly positively correlated with VEGF (r = 0.65, P < 0.001), TGF-β1 (r = 0.31, P < 0.05), and NO (r = 0.51, P < 0.001). CONCLUSION: These findings suggest an association between psoriasis disease severity and serum levels of VEGF, TGF-β1, and NO, which can be recognized as markers of the psoriasis severity. The modulation of their production may represent a therapeutic potential strategy for psoriasis.
BACKGROUND:Vascular endothelial growth factor (VEGF), transforming growth factor β1 (TGF-β1), and nitric oxide (NO) have been reported to be contributory factors to the pathogenesis of psoriasis vulgaris. In the current study, we aimed to investigate the association between the levels of VEGF, TGF-β1, and NO and psoriasis severity (as expressed by psoriasis area severity index, PASI). METHODS: Fifty-eight patients with psoriasis vulgaris and twenty-two controls were included in the study. The serum levels of VEGF and TGF-β1 were estimated by ELISA technique. The serum levels of NO were determined by colorimetric method. RESULTS: The serum levels of VEGF, TGF-β1, and NO were significantly higher in patients than controls. Moreover, the serum levels of the studied biochemical variables in patients with severe disease activity were significantly higher than mild cases. The duration of disease showed significant positive correlations with each VEGF (r = 0.35, P < 0.01) and TGF-β1 (r = 0.41, P < 0.05). In addition, the PASI score was significantly positively correlated with VEGF (r = 0.65, P < 0.001), TGF-β1 (r = 0.31, P < 0.05), and NO (r = 0.51, P < 0.001). CONCLUSION: These findings suggest an association between psoriasis disease severity and serum levels of VEGF, TGF-β1, and NO, which can be recognized as markers of the psoriasis severity. The modulation of their production may represent a therapeutic potential strategy for psoriasis.
Authors: A Balat; M Cekmen; M Yürekli; O Kutlu; I Islek; E Sönmezgöz; M Cakir; Y Türköz; S Yoloğlu Journal: Pediatr Nephrol Date: 2000-12 Impact factor: 3.714
Authors: Audrey Henno; Silvia Blacher; Charles A Lambert; Christophe Deroanne; Agnès Noël; Charles Lapière; Michel de la Brassinne; Betty V Nusgens; Alain Colige Journal: J Dermatol Sci Date: 2010-01-07 Impact factor: 4.563
Authors: Aline Lopes Bressan; Daniele Pereira; Paula Mota Medeiros; Sueli Carneiro; Luna Azulay-Abulafia Journal: An Bras Dermatol Date: 2017 Nov-Dec Impact factor: 1.896
Authors: Heba H El-Hadidi; Akmal S Hassan; Ghada El-Hanafy; Khalda S Amr; Sameh F Abdelmesih; Mahmoud F Abdelhamid Journal: Clin Cosmet Investig Dermatol Date: 2018-08-22
Authors: Christian S Thudium; Signe Holm Nielsen; Samra Sardar; Ali Mobasheri; Willem Evert van Spil; Rik Lories; Kim Henriksen; Anne-Christine Bay-Jensen; Morten A Karsdal Journal: BMC Musculoskelet Disord Date: 2020-11-28 Impact factor: 2.362