| Literature DB >> 24657728 |
Ilya Ulasov1, Ruiyang Yi2, Donna Guo2, Purvaba Sarvaiya2, Charles Cobbs3.
Abstract
Glioblastoma is a malignant brain tumor of glial origin. These tumors are thought to be derived from astrocytic cells that undergo malignant transformation. A growing body of evidence suggests that upregulation of MMP expression plays a significant role in promoting glioma pathogenesis. Elevated expression of MMP14 not only promotes glioma invasion and tumor cell proliferation but also plays a role in angiogenesis. Despite the fact that levels of MMP14 correlate with breast cancer progression, the controversial role of MMP14 in gliomagenesis needs to be elucidated. In the present review, we discuss the role of MMP14 in glioma progression as well as the mechanisms of MMP14 regulation in the context of future therapeutic manipulations.Entities:
Keywords: Angiogenesis; Brain; Glioblastoma; Invasion; MMP14; Tumor
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Year: 2014 PMID： 24657728 DOI： 10.1016/j.bbcan.2014.03.002
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002