Literature DB >> 24657659

GABAergic signaling facilitates breast cancer metastasis by promoting ERK1/2-dependent phosphorylation.

Depu Zhang1, Xiaowei Li1, Ziming Yao1, Chuanfei Wei1, Nannan Ning1, Jingxin Li2.   

Abstract

The present study aims to determine the role of γ-aminobutyric acid (GABA) signaling molecules in breast cancer metastasis. Our results reveal that GABAergic system exists in breast cancer cells. Both the GABA synthetic enzyme. (GAD65/67) and GABAB receptor are expressed in 4T1 mouse breast cancer cells, MCF-7 human breast cancer cells and human breast cancer tissue. Baclofen, a GABABR agonist, significantly promoted 4T1 cells invasion and migration in vitro and metastasis in vivo, an event that was attenuated by GABABR antagonist CGP55845. Baclofen-induced breast cancer metastasis was mediated by ERK1/2 pathway.
Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Entities:  

Keywords:  Breast cancer; ERK; GABA receptor; Metastasis; γ-Aminobutyric acid

Mesh：

Substances：

Year:  2014        PMID： 24657659     DOI： 10.1016/j.canlet.2014.03.006

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


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