Literature DB >> 24657445

3,5,6,7,8,3',4'-Heptamethoxyflavone, a citrus flavonoid, on protection against memory impairment and neuronal cell death in a global cerebral ischemia mouse model.

Satoshi Okuyama1, Mayu Morita2, Kazuhiro Miyoshi2, Yuki Nishigawa2, Miki Kaji2, Atsushi Sawamoto2, Tsukasa Terugo2, Nobuki Toyoda2, Nahomi Makihata2, Yoshiaki Amakura3, Morio Yoshimura3, Mitsunari Nakajima2, Yoshiko Furukawa2.   

Abstract

The present study evaluated the effects of treatment with the citrus flavonoid, 3,5,6,7,8,3',4'-heptamethoxyflavone (HMF) on protection against memory impairment and neuronal death in a global cerebral ischemia mouse model. The results showed that HMF, administrated for three days immediately after ischemic surgery, protected against ischemia-induced memory dysfunction, rescued neuronal cell death in the CA1 cell layer, increased the production of BDNF, stimulated the autophosphorylation of CaMK II and suppressed microglial activation in the hippocampus. These results suggest that HMF has a neuroprotective effect after brain ischemia by inducing BDNF production and anti-inflammatory effects.
Copyright © 2014 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Anti-inflammation; BDNF; Global cerebral ischemia; Heptamethoxyflavone; Hippocampus; Neuronal cell protection

Mesh：

Substances：

Year:  2014        PMID： 24657445     DOI： 10.1016/j.neuint.2014.03.008

Source DB:  PubMed          Journal:  Neurochem Int        ISSN： 0197-0186            Impact factor:   3.921


  11 in total

Review 1.  Neurotrophic function of phytochemicals for neuroprotection in aging and neurodegenerative disorders: modulation of intracellular signaling and gene expression.

Authors:  Makoto Naoi; Keiko Inaba-Hasegawa; Masayo Shamoto-Nagai; Wakako Maruyama
Journal:  J Neural Transm (Vienna)       Date:  2017-10-13       Impact factor: 3.575

2.  3,5,6,7,8,3',4'-heptamethoxyflavone, a citrus polymethoxylated flavone, attenuates inflammation in the mouse hippocampus.

Authors:  Satoshi Okuyama; Kazuhiro Miyoshi; Yuichi Tsumura; Yoshiaki Amakura; Morio Yoshimura; Takashi Yoshida; Mitsunari Nakajima; Yoshiko Furukawa
Journal:  Brain Sci       Date:  2015-04-15

3.  Edaravone enhances brain-derived neurotrophic factor production in the ischemic mouse brain.

Authors:  Satoshi Okuyama; Mayu Morita; Atsushi Sawamoto; Tsukasa Terugo; Mitsunari Nakajima; Yoshiko Furukawa
Journal:  Pharmaceuticals (Basel)       Date:  2015-04-02

Review 4.  Antidepressant Flavonoids and Their Relationship with Oxidative Stress.

Authors:  Lucian Hritcu; Radu Ionita; Paula Alexandra Postu; Girish Kumar Gupta; Hasan Turkez; Tamires Cardoso Lima; Caroline Uchôa Souza Carvalho; Damião Pergentino de Sousa
Journal:  Oxid Med Cell Longev       Date:  2017-12-19       Impact factor: 6.543

5.  Permeation of Polymethoxyflavones into the Mouse Brain and Their Effect on MK-801-Induced Locomotive Hyperactivity.

Authors:  Satoshi Okuyama; Kohei Miyazaki; Rie Yamada; Yoshiaki Amakura; Morio Yoshimura; Atsushi Sawamoto; Mitsunari Nakajima; Yoshiko Furukawa
Journal:  Int J Mol Sci       Date:  2017-02-24       Impact factor: 5.923

6.  Inhibitory Effects of Auraptene and Naringin on Astroglial Activation, Tau Hyperphosphorylation, and Suppression of Neurogenesis in the Hippocampus of Streptozotocin-Induced Hyperglycemic Mice.

Authors:  Satoshi Okuyama; Tatsumi Nakashima; Kumi Nakamura; Wakana Shinoka; Maho Kotani; Atsushi Sawamoto; Mitsunari Nakajima; Yoshiko Furukawa
Journal:  Antioxidants (Basel)       Date:  2018-08-19

Review 7.  Beneficial Effects of Citrus-Derived Polymethoxylated Flavones for Central Nervous System Disorders.

Authors:  Kentaro Matsuzaki; Yasushi Ohizumi
Journal:  Nutrients       Date:  2021-01-04       Impact factor: 5.717

8.  Involvement of the GABAergic system in the neuroprotective and sedative effects of acacetin 7-O-glucoside in rodents.

Authors:  Javier Gálvez; Rosa Estrada-Reyes; Gloria Benítez-King; Gabriela Araujo; Sandra Orozco; Rodrigo Fernández-Mas; Salvador Almazán; Eduardo Calixto
Journal:  Restor Neurol Neurosci       Date:  2015       Impact factor: 2.406

9.  3,5,6,7,8,3',4'-Heptamethoxyflavone, a Citrus Flavonoid, Inhibits Collagenase Activity and Induces Type I Procollagen Synthesis in HDFn Cells.

Authors:  Hong-Il Kim; Yong-Un Jeong; Jong-Hyeon Kim; Young-Jin Park
Journal:  Int J Mol Sci       Date:  2018-02-22       Impact factor: 5.923

Review 10.  Emerging Role of Flavonoids as the Treatment of Depression.

Authors:  Arzoo Pannu; Prabodh Chander Sharma; Vijay Kumar Thakur; Ramesh K Goyal
Journal:  Biomolecules       Date:  2021-12-03
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