Khaled Nazef1, Malika Khelil2, Hiba Chelouti1, Ghouti Kacimi3, Mohamed Bendini4, Meriem Tazir5, Soraya Belarbi5, Mohamed El Hadi Cherifi6, Bahia Djerdjouri1. 1. Département de Biologie Cellulaire et Moléculaire, Faculté des Sciences Biologiques, Université des Sciences et de la Technologie Houari Boumediene Alger, Algérie. 2. Département de Biologie Cellulaire et Moléculaire, Faculté des Sciences Biologiques, Université des Sciences et de la Technologie Houari Boumediene Alger, Algérie. Electronic address: malikakhelil@hotmail.fr. 3. Laboratoire de Biochimie, Hôpital Central de l'Armée Mohamed Nekkache Alger, Algérie. 4. Service de Neurologie, Hôpital Central de l'Armée Mohamed Nekkache Alger, Algérie. 5. Service de Neurologie, Centre Hospitalo-Universitaire (CHU) Mustapha Bacha Alger, Algérie. 6. Laboratoire Central de Biologie, Centre Hospitalo-Universitaire (CHU) Nafissa Hamoud Alger, Algérie.
Abstract
BACKGROUND AND AIMS: There is growing evidence that increased blood concentration of total homocysteine (tHcy) may be a risk factor for Alzheimer's disease (AD). The present study was conducted to evaluate the association of serum tHcy and other biochemical risk factors with AD. METHODS: This is a case-control study including 41 individuals diagnosed with AD and 46 nondemented controls. Serum levels of all studied biochemical parameters were performed. RESULTS: Univariate logistic regression showed a significant increase of tHcy (p = 0.008), urea (p = 0.036) and a significant decrease of vitamin B12 (p = 0.012) in AD group vs. controls. Using multivariate logistic regression, tHcy (p = 0.007, OR = 1.376) appeared as an independent risk factor predictor of AD. There was a significant positive correlation between tHcy and creatinine (p <0.0001). A negative correlation was found between tHcy and vitamin B12 (p <0.0001). CONCLUSIONS: Our findings support that hyperhomocysteinemia is a risk factor for AD in an Algerian population and is also associated with vitamin B12 deficiency.
BACKGROUND AND AIMS: There is growing evidence that increased blood concentration of total homocysteine (tHcy) may be a risk factor for Alzheimer's disease (AD). The present study was conducted to evaluate the association of serum tHcy and other biochemical risk factors with AD. METHODS: This is a case-control study including 41 individuals diagnosed with AD and 46 nondemented controls. Serum levels of all studied biochemical parameters were performed. RESULTS: Univariate logistic regression showed a significant increase of tHcy (p = 0.008), urea (p = 0.036) and a significant decrease of vitamin B12 (p = 0.012) in AD group vs. controls. Using multivariate logistic regression, tHcy (p = 0.007, OR = 1.376) appeared as an independent risk factor predictor of AD. There was a significant positive correlation between tHcy and creatinine (p <0.0001). A negative correlation was found between tHcy and vitamin B12 (p <0.0001). CONCLUSIONS: Our findings support that hyperhomocysteinemia is a risk factor for AD in an Algerian population and is also associated with vitamin B12deficiency.