BACKGROUND AND OBJECTIVES: The English transfusion service has screened donations from malaria-risk donors for malarial antibodies for over 10 years. The donor population includes migrants from many malaria-endemic countries and, from our experiences with post-transfusion malaria, some of these may remain parasitaemic and need clinical review. MATERIALS AND METHODS: Malarial antibody screen-reactive donations with serological evidence of malaria identified by the reference laboratory were further investigated for the presence of malarial DNA. RESULTS: Malarial DNA was found in 14 of 1955 samples investigated; three P. falciparum, five P. vivax, three P. ovale, two P. malariae and one dual parasitaemia P. falciparum/P. malariae. All of these were donors whose malaria risk was residency rather than travel. CONCLUSION: Malarial parasitaemia in healthy donors occurs, and donor malaria-risk strategies must take into account the possibility of such donors presenting. Countries not utilizing malarial antibody screening should consider carefully the collection of donations from donors previously resident in endemic countries; temporary deferral is insufficient.
BACKGROUND AND OBJECTIVES: The English transfusion service has screened donations from malaria-risk donors for malarial antibodies for over 10 years. The donor population includes migrants from many malaria-endemic countries and, from our experiences with post-transfusion malaria, some of these may remain parasitaemic and need clinical review. MATERIALS AND METHODS: Malarial antibody screen-reactive donations with serological evidence of malaria identified by the reference laboratory were further investigated for the presence of malarial DNA. RESULTS: Malarial DNA was found in 14 of 1955 samples investigated; three P. falciparum, five P. vivax, three P. ovale, two P. malariae and one dual parasitaemia P. falciparum/P. malariae. All of these were donors whose malaria risk was residency rather than travel. CONCLUSION:Malarial parasitaemia in healthy donors occurs, and donormalaria-risk strategies must take into account the possibility of such donors presenting. Countries not utilizing malarial antibody screening should consider carefully the collection of donations from donors previously resident in endemic countries; temporary deferral is insufficient.
Authors: Giselle F M C Lima; Maria C Arroyo Sanchez; José E Levi; Mahyumi Fujimori; Luiza Da Cruz Caramelo; Arianni Rondelli Sanchez; Eduardo M Ramos-Sanchez; Juliana Inoue; Maria De Jesus Costa-Nascimento; Alfredo Mendrone Junior; Silvia M Di Santi Journal: Blood Transfus Date: 2017-11-07 Impact factor: 3.443
Authors: Sheila F O'Brien; Sheila Ward; Pierre Gallian; Cécile Fabra; Josiane Pillonel; Alan D Kitchen; Katy Davison; Clive R Seed; Gilles Delage; Whitney R Steele; David A Leiby Journal: Blood Transfus Date: 2019-02-06 Impact factor: 3.443
Authors: Luciana M F Maselli; Debora Levy; Gabriel Z Laporta; Aline M Monteiro; Linah A Fukuya; Maria F Ferreira-da-Cruz; Claudio T Daniel-Ribeiro; Pedro E Dorlhiac-Llacer; Maria Anice M Sallum; Sérgio P Bydlowski Journal: Malar J Date: 2014-06-06 Impact factor: 2.979
Authors: Hong Lin; Shaowen Zhu; Shengjiang Zhu; Lei Shao; Nan Zhu; Chengyin Huang; Jun Sun Journal: Rev Inst Med Trop Sao Paulo Date: 2017-08-07 Impact factor: 1.846
Authors: Kelly M Searle; Ben Katowa; Tamaki Kobayashi; Mwiche N S Siame; Sungano Mharakurwa; Giovanna Carpi; Douglas E Norris; Jennifer C Stevenson; Philip E Thuma; William J Moss Journal: Malar J Date: 2017-04-19 Impact factor: 2.979