OBJECTIVES: Urinary tract infection (UTI) is the most common infectious complication after kidney transplantation. We aim to determine its impact on allograft function as indicated by several measures such as iothalamate glomerular filtration rate (iGFR), estimated glomerular filtration rate (eGFR), and creatinine value. METHODS: We performed a single-center retrospective cohort study to determine the impact of UTI on kidney allograft outcome. RESULTS: The study population consisted of 301 kidney transplant recipients; 84% were living donor transplants. One hundred and one patients (34%) developed at least one episode of UTI and the incidence of UTI during the first year after transplantation was 25%. At the end of the follow-up, the iGFR was lower among patients who had developed at least one UTI (p = 0.044). However, eGFR and creatinine values were not significantly different between UTI and non-UTI groups. CONCLUSION: When kidney function was measured by eGFR and creatinine, there was no significant difference in allograft function between kidney recipients with or without UTI. However, when kidney function was measured by nuclear studies, there was a tendency toward impairment in allograft function among patients who developed atleast one UTI after transplantation.
OBJECTIVES:Urinary tract infection (UTI) is the most common infectious complication after kidney transplantation. We aim to determine its impact on allograft function as indicated by several measures such as iothalamate glomerular filtration rate (iGFR), estimated glomerular filtration rate (eGFR), and creatinine value. METHODS: We performed a single-center retrospective cohort study to determine the impact of UTI on kidney allograft outcome. RESULTS: The study population consisted of 301 kidney transplant recipients; 84% were living donor transplants. One hundred and one patients (34%) developed at least one episode of UTI and the incidence of UTI during the first year after transplantation was 25%. At the end of the follow-up, the iGFR was lower among patients who had developed at least one UTI (p = 0.044). However, eGFR and creatinine values were not significantly different between UTI and non-UTI groups. CONCLUSION: When kidney function was measured by eGFR and creatinine, there was no significant difference in allograft function between kidney recipients with or without UTI. However, when kidney function was measured by nuclear studies, there was a tendency toward impairment in allograft function among patients who developed atleast one UTI after transplantation.
Authors: Krista L Lentine; Bertram L Kasiske; Andrew S Levey; Patricia L Adams; Josefina Alberú; Mohamed A Bakr; Lorenzo Gallon; Catherine A Garvey; Sandeep Guleria; Philip Kam-Tao Li; Dorry L Segev; Sandra J Taler; Kazunari Tanabe; Linda Wright; Martin G Zeier; Michael Cheung; Amit X Garg Journal: Transplantation Date: 2017-08 Impact factor: 4.939
Authors: Abhijit S Naik; Vikas R Dharnidharka; Mark A Schnitzler; Daniel C Brennan; Dorry L Segev; David Axelrod; Huiling Xiao; Lauren Kucirka; Jiajing Chen; Krista L Lentine Journal: Transpl Int Date: 2015-12-09 Impact factor: 3.782
Authors: Riti Mann; Daniel G Mediati; Iain G Duggin; Elizabeth J Harry; Amy L Bottomley Journal: Front Cell Infect Microbiol Date: 2017-06-08 Impact factor: 5.293
Authors: Philip Burnham; Darshana Dadhania; Michael Heyang; Fanny Chen; Lars F Westblade; Manikkam Suthanthiran; John Richard Lee; Iwijn De Vlaminck Journal: Nat Commun Date: 2018-06-20 Impact factor: 14.919