Ye Yuan1, Michelle L Duff1, Dawn L Sammons1, Shiyong Wu1. 1. Ye Yuan, Shiyong Wu, Edison Biotechnology Institute and Department of Chemistry and Biochemistry, Ohio University, Athens, OH 45701, United States.
Abstract
AIM: To investigate cancer cell absence or presence in wide excision after biopsy of squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) patients. METHODS: 200 patients (100 BCC and 100 SCC) from the same dermatology clinic, who had positive margin upon biopsy, were selected from a computer generated randomized report. All selected patients had wide excision following biopsy. To determine the correlation of gender, age distribution and cancer absence, BCC and SCC cases were separated based on excision-cancer absent or present after wide excision. χ(2) tests, Fisher's exact tests were used to analyze the ratio of male to female between excision-cancer absent and excision-cancer present patients, while Mann-Whitney U test were used to compare the age distribution in the two groups. Statistical analyses were performed using SPSS version 16.0 for Windows. RESULTS: Our retrospective chart review of the patients showed that cancer cells were absent in 49% of BCC patients (n = 100) and 64% of SCC patients (n = 100) who had previously had positive margins upon biopsy. Gender analysis showed the ratio of male to female (M/F) in the BCC arm was significantly higher compared with the SCC arm in those with excision-cancer absent (2.06 vs 0.66; P = 0.004; χ(2) test). But M/F of excision-cancer absent and excision-cancer present in neither BCC nor SCC patients was statistically significant. Age adjustment showed no significant difference between excision-cancer absent and excision-cancer present in BCC and SCC patients. Nevertheless, in excision-cancer absent cases, the age distribution showed that the BCC patients were younger than SCC patients (average age 67 vs 74; P < 0.001; Mann-Whitney U test). In addition, our data also indicated that in the patient group of 71-80 years old, there were more SCC patients who showed excision-cancer absence (67.6% vs 39.4%; P = 0.02; χ(2) test). CONCLUSION: Our study indicates that approximately 50% or more of BCC and SCC patients with positive margins found on biopsies did not have cancer cells present at the time of wide excisions.
AIM: To investigate cancer cell absence or presence in wide excision after biopsy of squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) patients. METHODS: 200 patients (100 BCC and 100 SCC) from the same dermatology clinic, who had positive margin upon biopsy, were selected from a computer generated randomized report. All selected patients had wide excision following biopsy. To determine the correlation of gender, age distribution and cancer absence, BCC and SCC cases were separated based on excision-cancer absent or present after wide excision. χ(2) tests, Fisher's exact tests were used to analyze the ratio of male to female between excision-cancer absent and excision-cancer present patients, while Mann-Whitney U test were used to compare the age distribution in the two groups. Statistical analyses were performed using SPSS version 16.0 for Windows. RESULTS: Our retrospective chart review of the patients showed that cancer cells were absent in 49% of BCC patients (n = 100) and 64% of SCCpatients (n = 100) who had previously had positive margins upon biopsy. Gender analysis showed the ratio of male to female (M/F) in the BCC arm was significantly higher compared with the SCC arm in those with excision-cancer absent (2.06 vs 0.66; P = 0.004; χ(2) test). But M/F of excision-cancer absent and excision-cancer present in neither BCC nor SCCpatients was statistically significant. Age adjustment showed no significant difference between excision-cancer absent and excision-cancer present in BCC and SCCpatients. Nevertheless, in excision-cancer absent cases, the age distribution showed that the BCC patients were younger than SCCpatients (average age 67 vs 74; P < 0.001; Mann-Whitney U test). In addition, our data also indicated that in the patient group of 71-80 years old, there were more SCCpatients who showed excision-cancer absence (67.6% vs 39.4%; P = 0.02; χ(2) test). CONCLUSION: Our study indicates that approximately 50% or more of BCC and SCCpatients with positive margins found on biopsies did not have cancer cells present at the time of wide excisions.
Authors: J Y Kwak; M K Han; K S Choi; I H Park; S Y Park; M H Sohn; U H Kim; J R McGregor; W E Samlowski; C Y Yim Journal: Cell Immunol Date: 2000-08-01 Impact factor: 4.868
Authors: Ethan Walker; Yiqiao Liu; InYoung Kim; David L Wilson; James P Basilion; Daniel L Popkin; Mark Biro; Sukanya Raj Iyer; Harib Ezaldein; Jeffrey Scott; Miesha Merati; Rachel Mistur; Bo Zhou; Brian Straight; Joshua J Yim; Matthew Bogyo; Margaret Mann Journal: Cancer Res Date: 2020-03-04 Impact factor: 12.701
Authors: Verena von Felbert; Dirk Bauerschlag; Nicolai Maass; Karen Bräutigam; Ivo Meinhold-Heerlein; Mira Woitok; Stefan Barth; Ahmad Fawzi Hussain Journal: J Cancer Res Clin Oncol Date: 2016-02-03 Impact factor: 4.553
Authors: C Malcolm M Stewart; Jared Garlick; Jaron Mcmullin; Faizi Siddiqi; Courtney Crombie; W Bradford Rockwell; Barbu Gociman Journal: Plast Reconstr Surg Glob Open Date: 2015-01-08