Literature DB >> 24653792

Fatty liver in childhood.

Yesim Ozturk1, Ozlem Bekem Soylu1.   

Abstract

Fatty liver is a growing health problem worldwide. It might evolve to nonalcoholic steatohepatitis, cirrhosis and cause hepatocellular carcinoma. This disease, which has increased because of eating habits, changes in food content and lifestyle, affects people from childhood. The most important risk factors are obesity and insulin resistance. Besides these factors, gender, ethnicity, genetic predisposition and some medical problems are also important. Cirrhosis in children is rare but is reported. Nonalcoholic fatty liver disease (NAFLD) has no specific symptoms or signs but should be considered in obese children. NAFLD does not have a proven treatment. Weight loss with family based treatments is the most acceptable management. Exercise and an applicable diet with low glycemic index and appropriate calorie intake are preferred. Drugs are promising but not sufficient in children for today.

Entities:  

Keywords:  Children; Chronic liver disease; Insulin resistance; Metabolic syndrome; Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; Obesity

Year:  2014        PMID: 24653792      PMCID: PMC3953806          DOI: 10.4254/wjh.v6.i1.33

Source DB:  PubMed          Journal:  World J Hepatol


  100 in total

1.  Ethnic differences in the link between insulin resistance and elevated ALT.

Authors:  Mark D Deboer; R Constance Wiener; Barrett H Barnes; Matthew J Gurka
Journal:  Pediatrics       Date:  2013-08-12       Impact factor: 7.124

2.  Triglyceride accumulation protects against fatty acid-induced lipotoxicity.

Authors:  Laura L Listenberger; Xianlin Han; Sarah E Lewis; Sylvaine Cases; Robert V Farese; Daniel S Ory; Jean E Schaffer
Journal:  Proc Natl Acad Sci U S A       Date:  2003-03-10       Impact factor: 11.205

3.  Medical consequences of childhood obesity: a Hong Kong perspective.

Authors:  Alice Pik Shan Kong; Chun Chung Chow
Journal:  Res Sports Med       Date:  2010-01       Impact factor: 4.674

4.  Ninety patients with nonalcoholic steatohepatitis: insulin resistance, familial tendency, and severity of disease.

Authors:  I R Willner; B Waters; S R Patil; A Reuben; J Morelli; C A Riely
Journal:  Am J Gastroenterol       Date:  2001-10       Impact factor: 10.864

5.  Serum adiponectin, resistin levels and non-alcoholic fatty liver disease in obese children.

Authors:  Chao Chun Zou; Li Liang; Fang Hong; Jun Feng Fu; Zheng Yan Zhao
Journal:  Endocr J       Date:  2005-10       Impact factor: 2.349

6.  Hepatic progenitor cells activation, fibrosis, and adipokines production in pediatric nonalcoholic fatty liver disease.

Authors:  Valerio Nobili; Guido Carpino; Anna Alisi; Antonio Franchitto; Gianfranco Alpini; Rita De Vito; Paolo Onori; Domenico Alvaro; Eugenio Gaudio
Journal:  Hepatology       Date:  2012-12       Impact factor: 17.425

Review 7.  Metabolic effects of fructose and the worldwide increase in obesity.

Authors:  Luc Tappy; Kim-Anne Lê
Journal:  Physiol Rev       Date:  2010-01       Impact factor: 37.312

8.  Beyond insulin resistance in NASH: TNF-alpha or adiponectin?

Authors:  Jason M Hui; Alex Hodge; Geoffrey C Farrell; James G Kench; Adamandia Kriketos; Jacob George
Journal:  Hepatology       Date:  2004-07       Impact factor: 17.425

9.  SAFETY study: alanine aminotransferase cutoff values are set too high for reliable detection of pediatric chronic liver disease.

Authors:  Jeffrey B Schwimmer; Winston Dunn; Gregory J Norman; Perrie E Pardee; Michael S Middleton; Nanda Kerkar; Claude B Sirlin
Journal:  Gastroenterology       Date:  2010-01-11       Impact factor: 22.682

10.  Noninvasive biomarkers for the diagnosis of steatohepatitis and advanced fibrosis in NAFLD.

Authors:  Steven G Pearce; Nirav C Thosani; Jen-Jung Pan
Journal:  Biomark Res       Date:  2013-02-04
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  4 in total

1.  Early redox imbalance is associated with liver dysfunction at weaning in overfed rats.

Authors:  E P S Conceição; E G Moura; J C Carvalho; E Oliveira; P C Lisboa
Journal:  J Physiol       Date:  2015-11-01       Impact factor: 5.182

Review 2.  Non-alcoholic fatty liver disease: The diagnosis and management.

Authors:  Shehab M Abd El-Kader; Eman M Salah El-Den Ashmawy
Journal:  World J Hepatol       Date:  2015-04-28

3.  Abdominal Subcutaneous Fat Thickness Measured by Ultrasonography Correlates with Hyperlipidemia and Steatohepatitis in Obese Children.

Authors:  Sung Hyun Lee; Dongwan Kim; Min Young Baek; Hann Tchah; Yeon Sun Kim; Eell Ryoo; Yun Mi Kim
Journal:  Pediatr Gastroenterol Hepatol Nutr       Date:  2015-06-29

Review 4.  Utilization of animal models to investigate nonalcoholic steatohepatitis-associated hepatocellular carcinoma.

Authors:  Jian Wu
Journal:  Oncotarget       Date:  2016-07-05
  4 in total

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