N Mahesh1, S A K Uroof Rahamthullah2, Guntipalli M Naidu3, Amudala Rajesh4, P Ravisekhar Babu5, J Muralinath Reddy6. 1. Department of Oral Medicine & Radiology, KLR's Lenora Institute of Dental Sciences, Rajahmundry, Andhra Pradesh, India. 2. Department of Oral and Maxillofacial Surgery, C K S Theja Institute of Dental Sciences, Tirupati, Andhra Pradesh, India. 3. Department of Public Health Dentistry, Drs. S & NR Siddhartha Institute of Dental Sciences, Chinaoutpally, Gannavaram, Andhra Pradesh, India. 4. Department of Oral & Maxillofacial Pathology, C K S Theja Institute of Dental Sciences, Tirupati, Andhra Pradesh, India. 5. Department of Conservative Dentistry, C K S Theja Institute of Dental Sciences, Tirupati, Andhra Pradesh, India. 6. Department of Oral & Maxillofacial Surgery, Sri Sai Dental College, Srikakulam, Andhra Pradesh, India.
Abstract
BACKGROUND: Oral cancer is associated initially by the presence of pre-malignant lesions or pre-malignant conditions. Oral Leukoplakia is one of the best-known pre-malignant lesions in the oral cavity that have the highest rate of malignant transformation. Numerous studies have shown an altered lipid profile in various cancers including head and neck cancers. An inverse relationship between plasma lipid profiles has been seen in oral cancer and pre-cancerous subjects. The present study evaluated the plasma lipid profiles in oral leukoplakia and controls. MATERIALS & METHODS: This study was done in department of Oral Medicine and Radiology, Sibar dental College and Konacc diagnostics. 30 patients were included in the study (15 patients with oral leukoplakia (histo-pathologically proven) and 15 patients for comparison of results as controls). Patients with cardiovascular diseases, uncontrolled diabetes mellitus, acute hepatitis and nephrosis were excluded from the sample and lipid profile assay was done by fully automated biochemistry analyser (EM-360). Paired-t and Scheffe tests were used to find statistical significance between two groups. RESULTS: The plasma lipid levels were estimated in between the two groups by arithmetic mean along with standard deviation. The lipid parameters included were Total cholesterol, HDL, LDL, VLDL, Triglycerides. The lipid parameters of the patients in between the two groups were compared and analysed. CONCLUSION: In this study TC, HDL, LDL, Triglyceride level analysis showed slightly lower levels in oral leukoplakia patients than that of the controls. Higher VLDL levels were observed in leukoplakia than the control group. How to cite the article: Mahesh N, Rahamthullah SA, Naidu GM, Rajesh A, Babu PR, Reddy JM. Alterations of Plasma lipid profile patterns in oral leukoplakia. J Int Oral Health 2014;6(1):78-84.
BACKGROUND:Oral cancer is associated initially by the presence of pre-malignant lesions or pre-malignant conditions. Oral Leukoplakia is one of the best-known pre-malignant lesions in the oral cavity that have the highest rate of malignant transformation. Numerous studies have shown an altered lipid profile in various cancers including head and neck cancers. An inverse relationship between plasma lipid profiles has been seen in oral cancer and pre-cancerous subjects. The present study evaluated the plasma lipid profiles in oral leukoplakia and controls. MATERIALS & METHODS: This study was done in department of Oral Medicine and Radiology, Sibar dental College and Konacc diagnostics. 30 patients were included in the study (15 patients with oral leukoplakia (histo-pathologically proven) and 15 patients for comparison of results as controls). Patients with cardiovascular diseases, uncontrolled diabetes mellitus, acute hepatitis and nephrosis were excluded from the sample and lipid profile assay was done by fully automated biochemistry analyser (EM-360). Paired-t and Scheffe tests were used to find statistical significance between two groups. RESULTS: The plasma lipid levels were estimated in between the two groups by arithmetic mean along with standard deviation. The lipid parameters included were Total cholesterol, HDL, LDL, VLDL, Triglycerides. The lipid parameters of the patients in between the two groups were compared and analysed. CONCLUSION: In this study TC, HDL, LDL, Triglyceride level analysis showed slightly lower levels in oral leukoplakiapatients than that of the controls. Higher VLDL levels were observed in leukoplakia than the control group. How to cite the article: Mahesh N, Rahamthullah SA, Naidu GM, Rajesh A, Babu PR, Reddy JM. Alterations of Plasma lipid profile patterns in oral leukoplakia. J Int Oral Health 2014;6(1):78-84.
Entities:
Keywords:
HDL; LDL; VLDL; plasma lipid profiles; total cholesterol; triglycerides
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