Shi-Qi Wen1, Quan Chen1, Ming Hu1. 1. Department of Vascular, Gansu Provincial Hospital, Lanzhou 730000, China.
Abstract
BACKGROUND: [corrected] Cantharidin, and its derivatives can not only inhibit the proliferation of tumor cells, but can also induce tumor cell apoptosis. It shows cantharidin exhibits a wide range of reactivity in anticancer. The objective of this paper was to study the inhibitory effect of sodium cantharidinate on human hepatoma HepG2 cells. MATERIALS AND METHODS: MTT assay was used to detect the proliferation of HepG2 cells, and immunohisto-chemical method was used to detect the change in VEGF, protein level, and to determine the inhibitory effect of sodium cantharidinate on human hepatoma HepG2 cells. RESULTS: As results, sodium cantharidinate significantly inhibited the growth of HepG2 cells in a time-and dose-dependent manner. CONCLUSION: We conclude that sodium cantharidinate has an inhibitory effect on human hepatoma HepG2 cells.
BACKGROUND: [corrected] Cantharidin, and its derivatives can not only inhibit the proliferation of tumor cells, but can also induce tumor cell apoptosis. It shows cantharidin exhibits a wide range of reactivity in anticancer. The objective of this paper was to study the inhibitory effect of sodium cantharidinate on humanhepatoma HepG2 cells. MATERIALS AND METHODS:MTT assay was used to detect the proliferation of HepG2 cells, and immunohisto-chemical method was used to detect the change in VEGF, protein level, and to determine the inhibitory effect of sodium cantharidinate on humanhepatoma HepG2 cells. RESULTS: As results, sodium cantharidinate significantly inhibited the growth of HepG2 cells in a time-and dose-dependent manner. CONCLUSION: We conclude that sodium cantharidinate has an inhibitory effect on humanhepatoma HepG2 cells.
Entities:
Keywords:
MTT assay; human hepatoma HepG2; sodium cantharidinate
Authors: Thomas Efferth; Rolf Rauh; Stefan Kahl; Maja Tomicic; Herbert Böchzelt; Margaret E Tome; Margaret M Briehl; Rudolf Bauer; Bernd Kaina Journal: Biochem Pharmacol Date: 2005-01-21 Impact factor: 5.858