Literature DB >> 24652964

A phase 2 trial of HQK-1001 in HbE-β thalassemia demonstrates HbF induction and reduced anemia.

Poramin Patthamalai1, Suthat Fuchareon, Nattawara Chaneiam, Richard G Ghalie, David H K Chui, Michael S Boosalis, Susan P Perrine.   

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Year:  2014        PMID： 24652964      PMCID： PMC3962168          DOI： 10.1182/blood-2013-11-538470

Source DB:  PubMed          Journal:  Blood        ISSN： 0006-4971            Impact factor:   22.113


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  10 in total

Review 1.  Control of fetal hemoglobin: new insights emerging from genomics and clinical implications.

Authors:  Swee Lay Thein; Stephan Menzel; Mark Lathrop; Chad Garner
Journal:  Hum Mol Genet       Date:  2009-10-15       Impact factor: 6.150

2.  Enhancement of growth and survival and alterations in Bcl-family proteins in beta-thalassemic erythroid progenitors by novel short-chain fatty acid derivatives.

Authors:  Serguei Castaneda; Michael S Boosalis; David Emery; Allison Thies; Douglas V Faller; Susan P Perrine
Journal:  Blood Cells Mol Dis       Date:  2005 Sep-Oct       Impact factor: 3.039

Review 3.  Changing patterns of thalassemia worldwide.

Authors:  Elliott P Vichinsky
Journal:  Ann N Y Acad Sci       Date:  2005       Impact factor: 5.691

4.  A genome-wide association identified the common genetic variants influence disease severity in beta0-thalassemia/hemoglobin E.

Authors:  Manit Nuinoon; Wattanan Makarasara; Taisei Mushiroda; Iswari Setianingsih; Pustika Amalia Wahidiyat; Orapan Sripichai; Natsuhiko Kumasaka; Atsushi Takahashi; Saovaros Svasti; Thongperm Munkongdee; Surakameth Mahasirimongkol; Chayanon Peerapittayamongkol; Vip Viprakasit; Naoyuki Kamatani; Pranee Winichagoon; Michiaki Kubo; Yusuke Nakamura; Suthat Fucharoen
Journal:  Hum Genet       Date:  2010-03       Impact factor: 4.132

Review 5.  The inherited diseases of hemoglobin are an emerging global health burden.

Authors:  David J Weatherall
Journal:  Blood       Date:  2010-03-16       Impact factor: 22.113

6.  Fetal globin gene inducers: novel agents and new potential.

Authors:  Susan P Perrine; Serguei A Castaneda; David H K Chui; Douglas V Faller; Ronald J Berenson; Noppadol Siritanaratku; Suthat Fucharoen
Journal:  Ann N Y Acad Sci       Date:  2010-08       Impact factor: 5.691

7.  A randomized phase I/II trial of HQK-1001, an oral fetal globin gene inducer, in β-thalassaemia intermedia and HbE/β-thalassaemia.

Authors:  Suthat Fucharoen; Adlette Inati; Noppadol Siritanaratku; Swee L Thein; William C Wargin; Suzanne Koussa; Ali Taher; Nattawara Chaneim; Michael Boosalis; Ronald Berenson; Susan P Perrine
Journal:  Br J Haematol       Date:  2013-03-27       Impact factor: 6.998

8.  BCL11A is a major HbF quantitative trait locus in three different populations with beta-hemoglobinopathies.

Authors:  Amanda E Sedgewick; Nadia Timofeev; Paola Sebastiani; Jason C C So; Edmond S K Ma; Li Chong Chan; Goonnapa Fucharoen; Supan Fucharoen; Cynara G Barbosa; Badri N Vardarajan; Lindsay A Farrer; Clinton T Baldwin; Martin H Steinberg; David H K Chui
Journal:  Blood Cells Mol Dis       Date:  2008-08-08       Impact factor: 3.039

9.  Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

Authors:  Manuela Uda; Renzo Galanello; Serena Sanna; Guillaume Lettre; Vijay G Sankaran; Weimin Chen; Gianluca Usala; Fabio Busonero; Andrea Maschio; Giuseppe Albai; Maria Grazia Piras; Natascia Sestu; Sandra Lai; Mariano Dei; Antonella Mulas; Laura Crisponi; Silvia Naitza; Isadora Asunis; Manila Deiana; Ramaiah Nagaraja; Lucia Perseu; Stefania Satta; Maria Dolores Cipollina; Carla Sollaino; Paolo Moi; Joel N Hirschhorn; Stuart H Orkin; Gonçalo R Abecasis; David Schlessinger; Antonio Cao
Journal:  Proc Natl Acad Sci U S A       Date:  2008-02-01       Impact factor: 11.205

10.  Overview on practices in thalassemia intermedia management aiming for lowering complication rates across a region of endemicity: the OPTIMAL CARE study.

Authors:  Ali T Taher; Khaled M Musallam; Mehran Karimi; Amal El-Beshlawy; Khawla Belhoul; Shahina Daar; Mohamed-SalahEldin Saned; Abdul-Hamid El-Chafic; Maria R Fasulo; Maria D Cappellini
Journal:  Blood       Date:  2009-12-23       Impact factor: 22.113
  10 in total
  8 in total

Review 1.  Fetal Hemoglobin Induction by Epigenetic Drugs.

Authors:  Donald Lavelle; James Douglas Engel; Yogen Saunthararajah
Journal:  Semin Hematol       Date:  2018-04-22       Impact factor: 3.851

Review 2.  Reevaluating the hype: four bacterial metabolites under scrutiny.

Authors:  E E Fröhlich; R Mayerhofer; P Holzer
Journal:  Eur J Microbiol Immunol (Bp)       Date:  2015-03-26

Review 3.  Evolution of hemoglobin loci and their regulatory elements.

Authors:  Sjaak Philipsen; Ross C Hardison
Journal:  Blood Cells Mol Dis       Date:  2017-08-09       Impact factor: 3.039

4.  Pharmacological Induction of Human Fetal Globin Gene in Hydroxyurea-Resistant Primary Adult Erythroid Cells.

Authors:  Yu-Chi Chou; Ruei-Lin Chen; Zheng-Sheng Lai; Jen-Shin Song; Yu-Sheng Chao; Che-Kun James Shen
Journal:  Mol Cell Biol       Date:  2015-05-18       Impact factor: 4.272

5.  Novel Inducers of Fetal Globin Identified through High Throughput Screening (HTS) Are Active In Vivo in Anemic Baboons and Transgenic Mice.

Authors:  Michael S Boosalis; Jose I Sangerman; Gary L White; Roman F Wolf; Ling Shen; Yan Dai; Emily White; Levi H Makala; Biaoru Li; Betty S Pace; Mehdi Nouraie; Douglas V Faller; Susan P Perrine
Journal:  PLoS One       Date:  2015-12-29       Impact factor: 3.240

Review 6.  Targeting sickle cell disease root-cause pathophysiology with small molecules.

Authors:  Yogen Saunthararajah
Journal:  Haematologica       Date:  2019-08-08       Impact factor: 9.941

7.  Trienone analogs of curcuminoids induce fetal hemoglobin synthesis via demethylation at Gγ-globin gene promoter.

Authors:  Khanita Nuamsee; Thipphawan Chuprajob; Wachirachai Pabuprapap; Pornrutsami Jintaridth; Thongperm Munkongdee; Phatchariya Phannasil; Jim Vadolas; Pornthip Chaichompoo; Apichart Suksamrarn; Saovaros Svasti
Journal:  Sci Rep       Date:  2021-04-20       Impact factor: 4.379

Review 8.  Genomic approaches to identifying targets for treating β hemoglobinopathies.

Authors:  Duyen A Ngo; Martin H Steinberg
Journal:  BMC Med Genomics       Date:  2015-07-29       Impact factor: 3.063
  8 in total

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