BACKGROUND: FOS has been implicated in the progression of renal disease including IgAN. In this study, we investigated whether polymorphisms of FOS family genes [FOS, FOSB, FOS-like antigen 1 (FOSL1), and FOSL2] were associated with immunoglobulin A nephropathy (IgAN) and the clinical phenotypes of IgAN patients. METHODS: We genotyped single nucleotide polymorphisms (SNPs) of FOS family genes (rs2239615 and rs7101 for FOS, rs12373539 and rs2282695 for FOSB, rs637571 for FOSL1, and rs925255 for FOSL2) using direct sequencing in 198 IgAN patients and 290 control subjects. RESULTS: No SNPs were associated with IgAN; however, in the analysis of clinical phenotypes, we found that rs637571 of FOSL1 was associated with podocyte foot process effacement of IgAN in additive (CT vs. TT vs. CC, P = 0.0031, OR = 2.08, 95% CI = 1.27-3.40) and dominant models (CT/TT vs. CC, P = 0.0034, OR = 2.50, 95% CI = 1.35-4.64). The frequency of genotypes containing the T allele was increased in IgAN patients with podocyte foot process effacement, compared to those without podocyte foot process effacement. CONCLUSION: These results suggest that FOSL1 may be related to IgAN severity.
BACKGROUND:FOS has been implicated in the progression of renal disease including IgAN. In this study, we investigated whether polymorphisms of FOS family genes [FOS, FOSB, FOS-like antigen 1 (FOSL1), and FOSL2] were associated with immunoglobulin A nephropathy (IgAN) and the clinical phenotypes of IgANpatients. METHODS: We genotyped single nucleotide polymorphisms (SNPs) of FOS family genes (rs2239615 and rs7101 for FOS, rs12373539 and rs2282695 for FOSB, rs637571 for FOSL1, and rs925255 for FOSL2) using direct sequencing in 198 IgANpatients and 290 control subjects. RESULTS: No SNPs were associated with IgAN; however, in the analysis of clinical phenotypes, we found that rs637571 of FOSL1 was associated with podocyte foot process effacement of IgAN in additive (CT vs. TT vs. CC, P = 0.0031, OR = 2.08, 95% CI = 1.27-3.40) and dominant models (CT/TT vs. CC, P = 0.0034, OR = 2.50, 95% CI = 1.35-4.64). The frequency of genotypes containing the T allele was increased in IgANpatients with podocyte foot process effacement, compared to those without podocyte foot process effacement. CONCLUSION: These results suggest that FOSL1 may be related to IgAN severity.
Authors: Jeroen K J Deegens; Henry B P M Dijkman; George F Borm; Eric J Steenbergen; José G van den Berg; Jan J Weening; Jack F M Wetzels Journal: Kidney Int Date: 2008-08-27 Impact factor: 10.612
Authors: Willmar D Patino; Omar Y Mian; Ju-Gyeong Kang; Satoaki Matoba; Linda D Bartlett; Brenda Holbrook; Hugh H Trout; Louis Kozloff; Paul M Hwang Journal: Proc Natl Acad Sci U S A Date: 2005-02-22 Impact factor: 11.205
Authors: M E Pagtalunan; P L Miller; S Jumping-Eagle; R G Nelson; B D Myers; H G Rennke; N S Coplon; L Sun; T W Meyer Journal: J Clin Invest Date: 1997-01-15 Impact factor: 14.808
Authors: M P Rastaldi; S Tunesi; F Ferrario; A Indaco; H Zou; P Napodano; G D'Amico Journal: Nephrol Dial Transplant Date: 1998-07 Impact factor: 5.992