| Literature DB >> 24652761 |
António Guerreiro1, Alessandro Poma, Kal Karim, Ewa Moczko, Jessica Takarada, Isabel Perez de Vargas-Sansalvador, Nicholas Turner, Elena Piletska, Cristiana Schmidt de Magalhães, Natalia Glazova, Anastasia Serkova, Aleksandra Omelianova, Sergey Piletsky.
Abstract
Here, the modulation of enzyme activity is presented by protein-imprinted nanoparticles produced using a solid-phase approach. Using trypsin as target, binding of the nanoparticles to the enzyme results in its inhibition or in stabilization, depending on the orientation of the immobilized enzyme used during imprinting.Entities:
Keywords: enzyme inhibition; molecular recognition; molecularly imprinted polymers; nanoparticles; supramolecular chemistry
Mesh：
Substances：
Year: 2014 PMID： 24652761 PMCID： PMC4681057 DOI： 10.1002/adhm.201300634
Source DB: PubMed Journal: Adv Healthc Mater ISSN： 2192-2640 Impact factor: 9.933