Dongfang Wang1, Jin Gu1, Ting Wang1, Zijian Ding1. 1. MOE Key Laboratory of Bioinformatics, TNLIST Bioinformatics Division / Center for Synthetic and Systems Biology, Department of Automation, Tsinghua University, Beijing 100084, China.
Abstract
SUMMARY: MicroRNAs (miRNAs), a class of small regulatory RNAs, play important roles in cancer initiation, progression and therapy. MiRNAs are found to regulate diverse cancer-related processes by targeting a large set of oncogenic and tumor-suppressive genes. To establish a high-confidence reference resource for studying the miRNA-regulated target genes and cellular processes in cancer, we manually curated 2259 entries of cancer-related miRNA regulations with direct experimental evidence from ∼9000 abstracts, covering more than 300 miRNAs and 829 target genes across 25 cancer tissues. A web-based portal named oncomiRDB, which provides both graphical and text-based interfaces, was developed for easily browsing and searching all the annotations. It should be a useful resource for both the computational analysis and experimental study on miRNA regulatory networks and functions in cancer. AVAILABILITY AND IMPLEMENTATION: http://bioinfo.au.tsinghua.edu.cn/oncomirdb/ CONTACT: jgu@tsinghua.edu.cn SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
SUMMARY: MicroRNAs (miRNAs), a class of small regulatory RNAs, play important roles in cancer initiation, progression and therapy. MiRNAs are found to regulate diverse cancer-related processes by targeting a large set of oncogenic and tumor-suppressive genes. To establish a high-confidence reference resource for studying the miRNA-regulated target genes and cellular processes in cancer, we manually curated 2259 entries of cancer-related miRNA regulations with direct experimental evidence from ∼9000 abstracts, covering more than 300 miRNAs and 829 target genes across 25 cancer tissues. A web-based portal named oncomiRDB, which provides both graphical and text-based interfaces, was developed for easily browsing and searching all the annotations. It should be a useful resource for both the computational analysis and experimental study on miRNA regulatory networks and functions in cancer. AVAILABILITY AND IMPLEMENTATION: http://bioinfo.au.tsinghua.edu.cn/oncomirdb/ CONTACT: jgu@tsinghua.edu.cn SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
Authors: Chun Jung Chen; Jennifer E Cox; Kristopher D Azarm; Karen N Wylie; Kevin D Woolard; Patricia A Pesavento; Christopher S Sullivan Journal: Virology Date: 2014-12-13 Impact factor: 3.616