Literature DB >> 24651481

Upregulation of RECK gene expression by small double-stranded RNA targeting the promoter region.

F Sakurai1, Y Nanjo2, S Okamoto2, M Tachibana2, H Mizuguchi3.   

Abstract

Recent studies have demonstrated that small double-stranded RNAs (dsRNAs) complementary to the promoter region of target genes enhance the expression of those genes following transfection into cells. Here we show that expression of the matrix metalloproteinase (MMP) inhibitor RECK is activated in the cultured tumor cell lines by transfection with dsRNA complementary to the promoter of the RECK gene, leading to suppression of the expression of MMPs and it inhibited tumor cell invasion. These results support the suggestion that dsRNA complementary to the promoter region of tumor suppressor genes would have potential as a novel antitumor agent.

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Year:  2014        PMID： 24651481     DOI： 10.1038/cgt.2014.12

Source DB:  PubMed          Journal:  Cancer Gene Ther        ISSN： 0929-1903            Impact factor:   5.987


  27 in total

1.  Rational siRNA design for RNA interference.

Authors:  Angela Reynolds; Devin Leake; Queta Boese; Stephen Scaringe; William S Marshall; Anastasia Khvorova
Journal:  Nat Biotechnol       Date:  2004-02-01       Impact factor: 54.908

2.  The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis.

Authors:  J Oh; R Takahashi; S Kondo; A Mizoguchi; E Adachi; R M Sasahara; S Nishimura; Y Imamura; H Kitayama; D B Alexander; C Ide; T P Horan; T Arakawa; H Yoshida; S Nishikawa; Y Itoh; M Seiki; S Itohara; C Takahashi; M Noda
Journal:  Cell       Date:  2001-12-14       Impact factor: 41.582

3.  Activation of LDL receptor expression by small RNAs complementary to a noncoding transcript that overlaps the LDLR promoter.

Authors:  Masayuki Matsui; Fuminori Sakurai; Sayda Elbashir; Donald J Foster; Muthiah Manoharan; David R Corey
Journal:  Chem Biol       Date:  2010-12-22

4.  Downregulation of RECK by promoter methylation correlates with lymph node metastasis in non-small cell lung cancer.

Authors:  Huang-Chou Chang; Chun-Yu Cho; Wen-Chun Hung
Journal:  Cancer Sci       Date:  2007-02       Impact factor: 6.716

5.  Small interfering RNA-induced transcriptional gene silencing in human cells.

Authors:  Kevin V Morris; Simon W-L Chan; Steven E Jacobsen; David J Looney
Journal:  Science       Date:  2004-08-05       Impact factor: 47.728

6.  Effect of chemical modifications on modulation of gene expression by duplex antigene RNAs that are complementary to non-coding transcripts at gene promoters.

Authors:  Jonathan K Watts; Dongbo Yu; Klaus Charisse; Christophe Montaillier; Pierre Potier; Muthiah Manoharan; David R Corey
Journal:  Nucleic Acids Res       Date:  2010-04-19       Impact factor: 16.971

7.  Regulation of matrix metalloproteinase-9 and inhibition of tumor invasion by the membrane-anchored glycoprotein RECK.

Authors:  C Takahashi; Z Sheng; T P Horan; H Kitayama; M Maki; K Hitomi; Y Kitaura; S Takai; R M Sasahara; A Horimoto; Y Ikawa; B J Ratzkin; T Arakawa; M Noda
Journal:  Proc Natl Acad Sci U S A       Date:  1998-10-27       Impact factor: 11.205

8.  Significance of methylation status and the expression of RECK mRNA in lung tissue of patients with NSCLC.

Authors:  M Pesta; V Kulda; O Topolcan; J Safranek; J Vrzalova; R Cerny; L Holubec
Journal:  Anticancer Res       Date:  2009-11       Impact factor: 2.480

9.  Promoter targeted small RNAs induce long-term transcriptional gene silencing in human cells.

Authors:  Peter G Hawkins; Sharon Santoso; Christopher Adams; Vasiliki Anest; Kevin V Morris
Journal:  Nucleic Acids Res       Date:  2009-03-20       Impact factor: 16.971

10.  Antisense transcripts are targets for activating small RNAs.

Authors:  Jacob C Schwartz; Scott T Younger; Ngoc-Bich Nguyen; Daniel B Hardy; Brett P Monia; David R Corey; Bethany A Janowski
Journal:  Nat Struct Mol Biol       Date:  2008-07-06       Impact factor: 15.369
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  4 in total

Review 1.  Reversion inducing cysteine rich protein with Kazal motifs and cardiovascular diseases: The RECKlessness of adverse remodeling.

Authors:  Jacob J Russell; Laurel A Grisanti; Scott M Brown; Chastidy A Bailey; Shawn B Bender; B Chandrasekar
Journal:  Cell Signal       Date:  2021-03-27       Impact factor: 4.850

2.  TMPRSS4 facilitates epithelial-mesenchymal transition of hepatocellular carcinoma and is a predictive marker for poor prognosis of patients after curative resection.

Authors:  Cheng-Hao Wang; Zhong-Yi Guo; Ze-Ting Chen; Xu-Ting Zhi; Deng-Ke Li; Zhao-Ru Dong; Zhi-Qiang Chen; San-Yuan Hu; Tao Li
Journal:  Sci Rep       Date:  2015-07-20       Impact factor: 4.379

3.  Targeted p53 activation by saRNA suppresses human bladder cancer cells growth and metastasis.

Authors:  Chenghe Wang; Qiangqiang Ge; Qingsong Zhang; Zhong Chen; Jia Hu; Fan Li; Zhangqun Ye
Journal:  J Exp Clin Cancer Res       Date:  2016-03-25

4.  Small activating RNA binds to the genomic target site in a seed-region-dependent manner.

Authors:  Xing Meng; Qian Jiang; Nannan Chang; Xiaoxia Wang; Chujun Liu; Jingwei Xiong; Huiqing Cao; Zicai Liang
Journal:  Nucleic Acids Res       Date:  2016-02-11       Impact factor: 16.971
  4 in total

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