Literature DB >> 24651013

From fly wings to targeted cancer therapies: a centennial for notch signaling.

Panagiotis Ntziachristos1, Jing Shan Lim2, Julien Sage3, Iannis Aifantis4.   

Abstract

Since Notch phenotypes in Drosophila melanogaster were first identified 100 years ago, Notch signaling has been extensively characterized as a regulator of cell-fate decisions in a variety of organisms and tissues. However, in the past 20 years, accumulating evidence has linked alterations in the Notch pathway to tumorigenesis. In this review, we discuss the protumorigenic and tumor-suppressive functions of Notch signaling, and dissect the molecular mechanisms that underlie these functions in hematopoietic cancers and solid tumors. Finally, we link these mechanisms and observations to possible therapeutic strategies targeting the Notch pathway in human cancers.
Copyright © 2014 Elsevier Inc. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2014        PMID： 24651013      PMCID： PMC4040351          DOI： 10.1016/j.ccr.2014.02.018

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  230 in total

1.  Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignancies.

Authors:  Patrick A Zweidler-McKay; Yiping He; Lanwei Xu; Carlos G Rodriguez; Fredrick G Karnell; Andrea C Carpenter; Jon C Aster; David Allman; Warren S Pear
Journal:  Blood       Date:  2005-08-23       Impact factor: 22.113

2.  Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling.

Authors:  Qinghua Zeng; Shenglin Li; Douglas B Chepeha; Thomas J Giordano; Jong Li; Honglai Zhang; Peter J Polverini; Jacques Nor; Jan Kitajewski; Cun-Yu Wang
Journal:  Cancer Cell       Date:  2005-07       Impact factor: 31.743

3.  Mutations in the human Jagged1 gene are responsible for Alagille syndrome.

Authors:  T Oda; A G Elkahloun; B L Pike; K Okajima; I D Krantz; A Genin; D A Piccoli; P S Meltzer; N B Spinner; F S Collins; S C Chandrasekharappa
Journal:  Nat Genet       Date:  1997-07       Impact factor: 38.330

4.  Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA.

Authors:  Jeffrey J Wilson; Rhett A Kovall
Journal:  Cell       Date:  2006-03-10       Impact factor: 41.582

Review 5.  Mechanisms governing metastatic dormancy and reactivation.

Authors:  Filippo G Giancotti
Journal:  Cell       Date:  2013-11-07       Impact factor: 41.582

6.  Notch signaling is activated in human hepatocellular carcinoma and induces tumor formation in mice.

Authors:  Augusto Villanueva; Clara Alsinet; Kilangsungla Yanger; Yujin Hoshida; Yiwei Zong; Sara Toffanin; Leonardo Rodriguez-Carunchio; Manel Solé; Swan Thung; Ben Z Stanger; Josep M Llovet
Journal:  Gastroenterology       Date:  2012-09-11       Impact factor: 22.682

7.  NOTCH1 and FBXW7 mutations have a favorable impact on early response to treatment, but not on outcome, in children with T-cell acute lymphoblastic leukemia (T-ALL) treated on EORTC trials 58881 and 58951.

Authors:  E Clappier; S Collette; N Grardel; S Girard; L Suarez; G Brunie; S Kaltenbach; K Yakouben; F Mazingue; A Robert; P Boutard; D Plantaz; P Rohrlich; P van Vlierberghe; C Preudhomme; J Otten; F Speleman; N Dastugue; S Suciu; Y Benoit; Y Bertrand; H Cavé
Journal:  Leukemia       Date:  2010-09-23       Impact factor: 11.528

8.  The tumor suppressor gene hCDC4 is frequently mutated in human T-cell acute lymphoblastic leukemia with functional consequences for Notch signaling.

Authors:  Alena Malyukova; Takeaki Dohda; Natalie von der Lehr; Shahab Akhoondi; Shahab Akhondi; Martin Corcoran; Mats Heyman; Charles Spruck; Dan Grandér; Urban Lendahl; Olle Sangfelt
Journal:  Cancer Res       Date:  2007-06-15       Impact factor: 12.701

9.  NOTCH1/FBXW7 mutation identifies a large subgroup with favorable outcome in adult T-cell acute lymphoblastic leukemia (T-ALL): a Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL) study.

Authors:  Vahid Asnafi; Agnès Buzyn; Sandrine Le Noir; Frédéric Baleydier; Arnauld Simon; Kheira Beldjord; Oumedaly Reman; Francis Witz; Thierry Fagot; Emmanuelle Tavernier; Pascal Turlure; Thibaut Leguay; Françoise Huguet; Jean-Paul Vernant; Francis Daniel; Marie-Christine Béné; Norbert Ifrah; Xavier Thomas; Hervé Dombret; Elizabeth Macintyre
Journal:  Blood       Date:  2008-12-23       Impact factor: 22.113

10.  Notch Signaling in T-Cell Development and T-ALL.

Authors:  Xiaoyu Li; Harald von Boehmer
Journal:  ISRN Hematol       Date:  2011-01-23
View more
  157 in total

1.  A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo.

Authors:  Laura R Saunders; Alexander J Bankovich; Wade C Anderson; Monette A Aujay; Sheila Bheddah; KristenAnn Black; Radhika Desai; Paul A Escarpe; Johannes Hampl; Amy Laysang; David Liu; Javier Lopez-Molina; Milly Milton; Albert Park; Marybeth A Pysz; Hui Shao; Brian Slingerland; Michael Torgov; Samuel A Williams; Orit Foord; Philip Howard; Jacek Jassem; Andrzej Badzio; Piotr Czapiewski; David H Harpole; Afshin Dowlati; Pierre P Massion; William D Travis; M Catherine Pietanza; J T Poirier; Charles M Rudin; Robert A Stull; Scott J Dylla
Journal:  Sci Transl Med       Date:  2015-08-26       Impact factor: 17.956

2.  Exogenous administration of DLK1 ameliorates hepatic steatosis and regulates gluconeogenesis via activation of AMPK.

Authors:  Y-H Lee; M R Yun; H M Kim; B H Jeon; B-C Park; B-W Lee; E S Kang; H C Lee; Y W Park; B-S Cha
Journal:  Int J Obes (Lond)       Date:  2015-08-28       Impact factor: 5.095

3.  RUMI is a novel negative prognostic marker and therapeutic target in non-small-cell lung cancer.

Authors:  May Chammaa; Agnes Malysa; Carlos Redondo; Hyejeong Jang; Wei Chen; Gerold Bepler; Rodrigo Fernandez-Valdivia
Journal:  J Cell Physiol       Date:  2018-06-28       Impact factor: 6.384

4.  A conserved major facilitator superfamily member orchestrates a subset of O-glycosylation to aid macrophage tissue invasion.

Authors:  Katarina Valoskova; Julia Biebl; Marko Roblek; Shamsi Emtenani; Attila Gyoergy; Michaela Misova; Aparna Ratheesh; Patricia Reis-Rodrigues; Kateryna Shkarina; Ida Signe Bohse Larsen; Sergey Y Vakhrushev; Henrik Clausen; Daria E Siekhaus
Journal:  Elife       Date:  2019-03-26       Impact factor: 8.140

Review 5.  Deubiquitinases: Pro-oncogenic Activity and Therapeutic Targeting in Blood Malignancies.

Authors:  Blanca T Gutierrez-Diaz; Wei Gu; Panagiotis Ntziachristos
Journal:  Trends Immunol       Date:  2020-03-02       Impact factor: 16.687

Review 6.  Molecular biology and immunology of head and neck cancer.

Authors:  Theresa Guo; Joseph A Califano
Journal:  Surg Oncol Clin N Am       Date:  2015-04-20       Impact factor: 3.495

7.  Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer.

Authors:  Tanya Stoyanova; Mireille Riedinger; Shu Lin; Claire M Faltermeier; Bryan A Smith; Kelvin X Zhang; Catherine C Going; Andrew S Goldstein; John K Lee; Justin M Drake; Meghan A Rice; En-Chi Hsu; Behdokht Nowroozizadeh; Brandon Castor; Sandra Y Orellana; Steven M Blum; Donghui Cheng; Kenneth J Pienta; Robert E Reiter; Sharon J Pitteri; Jiaoti Huang; Owen N Witte
Journal:  Proc Natl Acad Sci U S A       Date:  2016-09-30       Impact factor: 11.205

Review 8.  Cellular and molecular biology of small cell lung cancer: an overview.

Authors:  Niki Karachaliou; Sara Pilotto; Chiara Lazzari; Emilio Bria; Filippo de Marinis; Rafael Rosell
Journal:  Transl Lung Cancer Res       Date:  2016-02

9.  Notch1 Autoactivation via Transcriptional Regulation of Furin, Which Sustains Notch1 Signaling by Processing Notch1-Activating Proteases ADAM10 and Membrane Type 1 Matrix Metalloproteinase.

Authors:  Hong Qiu; Xiaoying Tang; Jun Ma; Khvaramze Shaverdashvili; Keman Zhang; Barbara Bedogni
Journal:  Mol Cell Biol       Date:  2015-08-17       Impact factor: 4.272

10.  Notch1 regulates tongue cancer cells proliferation, apoptosis and invasion.

Authors:  Rui-Huan Gan; Hua Wei; Jing Xie; Dan-Ping Zheng; Er-Ling Luo; Xiao-Yu Huang; Jian Xie; Yong Zhao; Lin-Can Ding; Bo-Hua Su; Li-Song Lin; Da-Li Zheng; You-Guang Lu
Journal:  Cell Cycle       Date:  2017-12-21       Impact factor: 4.534
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.