Guo-wei Zhang1, Jian-hua Lin2, Jian-ping Qian3, Jie Zhou4. 1. Department of Hepatobiliary Surgery, NanFang Hospital, Southern Medical University, No. 1838, North Guangzhou Avenue, Guangzhou 510515, PR China. Electronic address: guoweizhang77@hotmail.com. 2. Department of Hepatobiliary Surgery, NanFang Hospital, Southern Medical University, No. 1838, North Guangzhou Avenue, Guangzhou 510515, PR China. Electronic address: jianhualin66@gmail.com. 3. Department of Hepatobiliary Surgery, NanFang Hospital, Southern Medical University, No. 1838, North Guangzhou Avenue, Guangzhou 510515, PR China. Electronic address: qjp1982@gmail.com. 4. Department of Hepatobiliary Surgery, NanFang Hospital, Southern Medical University, No. 1838, North Guangzhou Avenue, Guangzhou 510515, PR China. Electronic address: zhoujie01@medmail.com.cn.
Abstract
BACKGROUND: Alcoholic chronic pancreatitis (ACP) is the dominant cause of chronic pancreatitis (CP). As a main complication of CP, the formation of pancreatic duct stones (PDS) compromises pancreatic function and symptomatic patients are often subjected to aggressive treatments. The present study aimed to identify PDS risk factors in patients with ACP. METHODS: A retrospective analysis of 93 ACP patients was performed; patients were divided into two groups: ACP with PDS (n = 48) and ACP without PDS (n = 45). Fourteen potential factors were analyzed by univariate and multivariate analyses to identify independent risk factors of PDS formation in ACP patients. A comparison of demographic and clinical characteristics between ACP patients with PDS and non-ACP patients with PDS (n = 43) was also carried out. RESULTS: ACP accounted for 47.7% (93/195) of CP in this cohort. Among ACP patients, the morbidity of PDS was 51.6% (48/93). Significant risk factors of PDS formation for ACP patients included duration of drinking ≥24.7 years (OR, 9.036; 95% CI, 2.737-29.837; p < 0.001); daily alcohol consumption ≥147.0 g (OR, 3.147; 95% CI, 1.040-9.522; p = 0.042); and MPD narrowing (OR, 7.245; 95% CI, 2.205-23.811; p = 0.001). Shorter periods between diagnosis and PDS formation (PDP) were observed in ACP patients than non-ACP patients. CONCLUSIONS: Alcohol consumption accelerates the progression of PDS formation in patients with CP.
BACKGROUND:Alcoholic chronic pancreatitis (ACP) is the dominant cause of chronic pancreatitis (CP). As a main complication of CP, the formation of pancreatic duct stones (PDS) compromises pancreatic function and symptomatic patients are often subjected to aggressive treatments. The present study aimed to identify PDS risk factors in patients with ACP. METHODS: A retrospective analysis of 93 ACPpatients was performed; patients were divided into two groups: ACP with PDS (n = 48) and ACP without PDS (n = 45). Fourteen potential factors were analyzed by univariate and multivariate analyses to identify independent risk factors of PDS formation in ACPpatients. A comparison of demographic and clinical characteristics between ACPpatients with PDS and non-ACPpatients with PDS (n = 43) was also carried out. RESULTS:ACP accounted for 47.7% (93/195) of CP in this cohort. Among ACPpatients, the morbidity of PDS was 51.6% (48/93). Significant risk factors of PDS formation for ACPpatients included duration of drinking ≥24.7 years (OR, 9.036; 95% CI, 2.737-29.837; p < 0.001); daily alcohol consumption ≥147.0 g (OR, 3.147; 95% CI, 1.040-9.522; p = 0.042); and MPD narrowing (OR, 7.245; 95% CI, 2.205-23.811; p = 0.001). Shorter periods between diagnosis and PDS formation (PDP) were observed in ACPpatients than non-ACPpatients. CONCLUSIONS:Alcohol consumption accelerates the progression of PDS formation in patients with CP.
Authors: Sohail Z Husain; Veronique Morinville; John Pohl; Maisam Abu-El-Haija; Melena D Bellin; Steve Freedman; Peter Hegyi; Melvin B Heyman; Ryan Himes; Chee Y Ooi; Sarah J Schwarzenberg; Danielle Usatin; Aliye Uc Journal: J Pediatr Gastroenterol Nutr Date: 2016-04 Impact factor: 2.839