| Literature DB >> 24650521 |
Shozab S Ali1, Ebenezer T Oni2, Haider J Warraich3, Michael J Blaha4, Roger S Blumenthal4, Adil Karim2, Sameer Shaharyar2, Omar Jamal2, Jonathan Fialkow5, Ricardo Cury5, Matthew J Budoff6, Arthur S Agatston2, Khurram Nasir7.
Abstract
Patients with obstructive sleep apnea (OSA) have a high burden of cardiovascular disease (CVD) but a causal relationship between OSA and atherosclerotic CVD remains unclear. We systematically reviewed the literature analyzing the relationship. A review of the Medline database for studies noninvasively evaluating subclinical CVD in OSA was conducted. A total of fifty-two studies were included in this review. Across the studies the prevalence of atherosclerosis, as assessed by coronary artery calcification, carotid intima-media thickness, brachial artery flow-mediated dilation and pulse wave velocity was higher in patients with OSA and correlated with increasing severity and duration of OSA. This study shows OSA is an independent predictor of subclinical CVD as CVD is more likely to occur in patients with long standing and severe OSA. Further research is however necessary to identify specific OSA populations that would benefit from aggressive screening.Entities:
Keywords: Atherosclerosis; Cardiovascular disease; Coronary artery calcium; Endothelial dysfunction; Flow-mediated dilation; Intima media thickness; Obstructive sleep apnea; Pulse wave velocity
Mesh：
Year: 2014 PMID： 24650521 DOI： 10.1016/j.smrv.2014.01.004
Source DB: PubMed Journal: Sleep Med Rev ISSN： 1087-0792 Impact factor: 11.609