| Literature DB >> 2465003 |
E R Lazarowski1, E G Lapetina.
Abstract
Fluoride interacts with G proteins and, consequently, stimulates phospholipase C as measured by the formation of inositol phosphates and phosphatidic acid. In human platelets this paralleled platelet aggregation and the activation of phosphorylation of substrates of protein kinase C (47kDa protein) and myosin light chain kinase (20kDa protein). Phospholipase C activation by fluoride was inhibited by dibutyryl cyclic AMP and by agents that increase cyclic AMP levels such as iloprost and forskolin. This information suggest that cyclic AMP affects the G protein associated with the stimulation of phospholipase C.Entities:
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Year: 1989 PMID： 2465003 DOI： 10.1016/s0006-291x(89)80067-1
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575