OBJECTIVE: To evaluate effects of maropitant, acepromazine, and electroacupuncture on morphine-related signs of nausea and vomiting in dogs and assess sedative effects of the treatments. DESIGN: Randomized controlled clinical trial. ANIMALS: 222 dogs. PROCEDURES: Dogs received 1 of 6 treatments: injection of saline (0.9% NaCl) solution, maropitant citrate, or acepromazine maleate or electroacupuncture treatment at 1 acupoint, 5 acupoints, or a sham acupoint. Morphine was administered after 20 minutes of electroacupuncture treatment or 20 minutes after injectable treatment. Vomiting and retching events and signs of nausea and sedation were recorded. RESULTS: Incidence of vomiting and retching was significantly lower in the maropitant (14/37 [37.8%]) group than in the saline solution (28/37 [75.7%]) and sham-acupoint electroacupuncture (32/37 [86.5%]) groups. The number of vomiting and retching events in the maropitant (21), acepromazine (38), 1-acupoint (35), and 5-acupoint (34) groups was significantly lower than in the saline solution (88) and sham-acupoint electroacupuncture (109) groups. Incidence of signs of nausea was significantly lower in the acepromazine group (3/37 [8.1%]) than in the sham-acupoint group (15/37 [40.5%]). Mean nausea scores for the saline solution, maropitant, and sham-acupoint electroacupuncture groups increased significantly after morphine administration, whereas those for the acepromazine, 1-acupoint electroacupuncture, and 5-acupoint electroacupuncture groups did not. Mean sedation scores after morphine administration were significantly higher in dogs that received acepromazine than in dogs that received saline solution, maropitant, and sham-acupoint electroacupuncture treatment. CONCLUSIONS AND CLINICAL RELEVANCE: Maropitant treatment was associated with a lower incidence of vomiting and retching, compared with control treatments, and acepromazine and electroacupuncture appeared to prevent an increase in severity of nausea following morphine administration in dogs.
OBJECTIVE: To evaluate effects of maropitant, acepromazine, and electroacupuncture on morphine-related signs of nausea and vomiting in dogs and assess sedative effects of the treatments. DESIGN: Randomized controlled clinical trial. ANIMALS: 222 dogs. PROCEDURES: Dogs received 1 of 6 treatments: injection of saline (0.9% NaCl) solution, maropitant citrate, or acepromazine maleate or electroacupuncture treatment at 1 acupoint, 5 acupoints, or a sham acupoint. Morphine was administered after 20 minutes of electroacupuncture treatment or 20 minutes after injectable treatment. Vomiting and retching events and signs of nausea and sedation were recorded. RESULTS: Incidence of vomiting and retching was significantly lower in the maropitant (14/37 [37.8%]) group than in the saline solution (28/37 [75.7%]) and sham-acupoint electroacupuncture (32/37 [86.5%]) groups. The number of vomiting and retching events in the maropitant (21), acepromazine (38), 1-acupoint (35), and 5-acupoint (34) groups was significantly lower than in the saline solution (88) and sham-acupoint electroacupuncture (109) groups. Incidence of signs of nausea was significantly lower in the acepromazine group (3/37 [8.1%]) than in the sham-acupoint group (15/37 [40.5%]). Mean nausea scores for the saline solution, maropitant, and sham-acupoint electroacupuncture groups increased significantly after morphine administration, whereas those for the acepromazine, 1-acupoint electroacupuncture, and 5-acupoint electroacupuncture groups did not. Mean sedation scores after morphine administration were significantly higher in dogs that received acepromazine than in dogs that received saline solution, maropitant, and sham-acupoint electroacupuncture treatment. CONCLUSIONS AND CLINICAL RELEVANCE: Maropitant treatment was associated with a lower incidence of vomiting and retching, compared with control treatments, and acepromazine and electroacupuncture appeared to prevent an increase in severity of nausea following morphine administration in dogs.
Authors: Augusto M Lorenzutti; Manuel Martín-Flores; Nicolás J Litterio; Martín A Himelfarb; Sergio H Invaldi; María P Zarazaga Journal: Can Vet J Date: 2017-01 Impact factor: 1.008
Authors: Olawale Alimi Alimi; Adamu Abdul Abubakar; Abubakar Sadiq Yakubu; Abdullahi Aliyu; Salman Zubairu Abulkadir Journal: Open Vet J Date: 2020-07-29
Authors: Lea Henze; Sarah Foth; Sebastian Meller; Friederike Twele; Marios Charalambous; Hannah Kenward; Jonathan Elliott; Ludovic Pelligand; Holger A Volk Journal: J Vet Intern Med Date: 2022-07-29 Impact factor: 3.175
Authors: M A Memon; J Shmalberg; H S Adair; S Allweiler; J N Bryan; S Cantwell; E Carr; C Chrisman; C M Egger; S Greene; K K Haussler; B Hershey; G R Holyoak; M Johnson; S Le Jeune; A Looney; R S McConnico; C Medina; A J Morton; A Munsterman; G J Nie; N Park; M Parsons-Doherty; J A Perdrizet; J L Peyton; D Raditic; H P Ramirez; J Saik; S Robertson; M Sleeper; J Van Dyke; J Wakshlag Journal: Open Vet J Date: 2016-03-28