Literature DB >> 24649950

Polypharmacology: the rise of multitarget drugs over combination therapies.

Michela Rosini1.   

Abstract

Mesh：

Year:  2014        PMID： 24649950     DOI： 10.4155/fmc.14.25

Source DB:  PubMed          Journal:  Future Med Chem        ISSN： 1756-8919            Impact factor:   3.808


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  18 in total

1.  Introducing the metacore concept for multi-target ligand design.

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Journal:  RSC Med Chem       Date:  2021-04-15

2.  In Vivo Characterization of ARN14140, a Memantine/Galantamine-Based Multi-Target Compound for Alzheimer's Disease.

Authors:  Angelo M Reggiani; Elena Simoni; Roberta Caporaso; Johann Meunier; Emeline Keller; Tangui Maurice; Anna Minarini; Michela Rosini; Andrea Cavalli
Journal:  Sci Rep       Date:  2016-09-09       Impact factor: 4.379

3.  The Human Kinome Targeted by FDA Approved Multi-Target Drugs and Combination Products: A Comparative Study from the Drug-Target Interaction Network Perspective.

Authors:  Ying Hong Li; Pan Pan Wang; Xiao Xu Li; Chun Yan Yu; Hong Yang; Jin Zhou; Wei Wei Xue; Jun Tan; Feng Zhu
Journal:  PLoS One       Date:  2016-11-09       Impact factor: 3.240

4.  Novel conjugates of aminoadamantanes with carbazole derivatives as potential multitarget agents for AD treatment.

Authors:  Sergey O Bachurin; Elena F Shevtsova; Galina F Makhaeva; Vladimir V Grigoriev; Natalia P Boltneva; Nadezhda V Kovaleva; Sofya V Lushchekina; Pavel N Shevtsov; Margarita E Neganova; Olga M Redkozubova; Elena V Bovina; Alexey V Gabrelyan; Vladimir P Fisenko; Vladimir B Sokolov; Alexey Yu Aksinenko; Valentina Echeverria; George E Barreto; Gjumrakch Aliev
Journal:  Sci Rep       Date:  2017-03-30       Impact factor: 4.379

5.  Isatin thiazoline hybrids as dual inhibitors of HIV-1 reverse transcriptase.

Authors:  Rita Meleddu; Simona Distinto; Angela Corona; Enzo Tramontano; Giulia Bianco; Claudia Melis; Filippo Cottiglia; Elias Maccioni
Journal:  J Enzyme Inhib Med Chem       Date:  2016-10-21       Impact factor: 5.051

6.  X-ray Structure-Based Chemoinformatic Analysis Identifies Promiscuous Ligands Binding to Proteins from Different Classes with Varying Shapes.

Authors:  Christian Feldmann; Jürgen Bajorath
Journal:  Int J Mol Sci       Date:  2020-05-27       Impact factor: 5.923

7.  Structure-Based Discovery of Dual-Target Hits for Acetylcholinesterase and the α7 Nicotinic Acetylcholine Receptors: In Silico Studies and In Vitro Confirmation.

Authors:  Sebastian Oddsson; Natalia M Kowal; Philip K Ahring; Elin S Olafsdottir; Thomas Balle
Journal:  Molecules       Date:  2020-06-22       Impact factor: 4.411

8.  X-ray-Structure-Based Identification of Compounds with Activity against Targets from Different Families and Generation of Templates for Multitarget Ligand Design.

Authors:  Erik Gilberg; Dagmar Stumpfe; Jürgen Bajorath
Journal:  ACS Omega       Date:  2018-01-05

9.  Isatin: a privileged scaffold for the design of carbonic anhydrase inhibitors.

Authors:  Claudia Melis; Rita Meleddu; Andrea Angeli; Simona Distinto; Giulia Bianco; Clemente Capasso; Filippo Cottiglia; Rossella Angius; Claudiu T Supuran; Elias Maccioni
Journal:  J Enzyme Inhib Med Chem       Date:  2016-10-24       Impact factor: 5.051

10.  Discovery of Novel Inhibitors Targeting Multi-UDP-hexose Pyrophosphorylases as Anticancer Agents.

Authors:  Yueqin Yang; Hariprasad Vankayalapati; Manshu Tang; Yingbo Zheng; Yingri Li; Cong Ma; Kent Lai
Journal:  Molecules       Date:  2020-02-03       Impact factor: 4.411
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