| Literature DB >> 2464992 |
N D Carter1, P J Wistrand, H Isenberg, H Askmark, S Jeffery, D Hopkinson, Y Edwards.
Abstract
Carbonic anhydrase III (CAIII) protein and mRNA amounts in fast- and slow-twitch rat muscles were examined after resection of the sciatic nerve. Striking changes occur in the fast-twitch anterior tibialis (AT) and extensor digitorum longus (EDL) muscles, where CAIII protein and mRNA are increased several-fold 16 days after denervation. The data suggest that these changes are regulated in part by changes in gene transcription and that they perhaps signal a fast-to-slow fibre type transition in these denervated muscles. AT and EDL show some differences in the effects of denervation, which are suggestive of variation in the timing of denervation-induced responses and/or the CAIII protein/mRNA turnover rates in the two muscles.Entities:
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Year: 1988 PMID： 2464992 PMCID： PMC1135380 DOI： 10.1042/bj2560147
Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857