Association of a polymorphism of BTN2A1 with chronic kidney disease in community-dwelling individuals.

Results of recent studies have shown that the C→T polymorphism (rs6929846) of the butyrophilin, subfamily 2, member A1 gene (BTN2A1) was significantly associated with myocardial infarction. The aim of the current study was to examine the association of rs6929846 of BTN2A1 with chronic kidney disease (CKD) in community-dwelling individuals. Study subjects comprised 1,709 community-dwelling individuals, including 435 subjects with CKD [estimated glomerular filtration rate (eGFR) <60 ml/min per 1.73 m2] and 1,274 controls (eGFR≥90 ml/min per 1.73 m2) who were recruited to a population-based cohort study. Genotype distributions (P=0.0010) and allele frequencies (P=0.0002) of rs6929846 were significantly associated with CKD. Multivariate logistic regression analysis with adjustment for covariates revealed that the rs6929846 of BTN2A1 was significantly (P=0.0002; odds ratio, 2.02; dominant model) associated with CKD, with the minor T allele representing a risk for this condition. The serum concentrations of creatinine were significantly (P=0.0107) higher for all the individuals, whereas eGFR was significantly (P=0.0468) lower for individuals in the combined group of CT and TT genotypes compared to those with the CC genotype. BTN2A1 may therefore be a susceptibility gene for CKD.