Literature DB >> 24648974

Serum microRNAs: A new diagnostic method for colorectal cancer.

Yi Yang1, Xiaodong Gu1, Minwei Zhou1, Jianbin Xiang1, Zongyou Chen1.   

Abstract

Colorectal cancer (CRC) is the third most common malignant tumor worldwide, affecting over 1.23 million individuals annually. Over the past several years, the role of microRNAs (miRNAs) in CRC cells have been extensively investigated. Recently, it was discovered that extracellular miRNAs circulate in the blood of healthy individuals as well as CRC patients. Serum circulating miRNAs as novel biomarkers may be a new approach to CRC diagnosis. However, their secretory mechanism and biological function have not been fully elucidated. In this review, the main serum miRNAs used as potential diagnostic biomarkers for CRC, such as miR-92, miR-141, miR-29a, miR-21, miR-221, miR-601 and miR-760, were summarized. In addition, the mechanism of miRNA secretion from CRC cells was discussed. It is recommended that additional studies focus on the usefulness of serum miRNAs for early CRC diagnosis, prognosis and therapeutics.

Entities:  

Keywords:  colorectal cancer; diagnosis; microRNA

Year:  2013        PMID: 24648974      PMCID: PMC3917018          DOI: 10.3892/br.2013.109

Source DB:  PubMed          Journal:  Biomed Rep        ISSN: 2049-9434


  40 in total

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Journal:  Sci Signal       Date:  2009-12-08       Impact factor: 8.192

4.  Circulating miR-221 directly amplified from plasma is a potential diagnostic and prognostic marker of colorectal cancer and is correlated with p53 expression.

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  18 in total

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Journal:  Cell Prolif       Date:  2014-10-27       Impact factor: 6.831

3.  miR-503 inhibits cell proliferation and induces apoptosis in colorectal cancer cells by targeting E2F3.

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Journal:  Int J Clin Exp Pathol       Date:  2015-10-01

4.  Cell-autonomous and cell non-autonomous downregulation of tumor suppressor DAB2IP by microRNA-149-3p promotes aggressiveness of cancer cells.

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Journal:  Cell Death Differ       Date:  2018-03-22       Impact factor: 15.828

5.  Effects of preanalytic variables on circulating microRNAs in whole blood.

Authors:  Hua Zhao; Jie Shen; Qiang Hu; Warren Davis; Leonardo Medico; Dan Wang; Li Yan; Yuqing Guo; Biao Liu; Maochun Qin; Mary Nesline; Qianqian Zhu; Song Yao; Christine B Ambrosone; Song Liu
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Review 6.  Survival Benefit and Safety of Bevacizumab in Combination with Erlotinib as Maintenance Therapy in Patients with Metastatic Colorectal Cancer: A Meta-Analysis.

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Journal:  Clin Drug Investig       Date:  2017-02       Impact factor: 2.859

7.  Combined detection of serum exosomal miR-21 and HOTAIR as diagnostic and prognostic biomarkers for laryngeal squamous cell carcinoma.

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Review 8.  Regulatory role of small nucleolar RNAs in human diseases.

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9.  Folic acid supplements and colorectal cancer risk: meta-analysis of randomized controlled trials.

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10.  Serum microRNA 143 and microRNA 215 as potential biomarkers for the diagnosis of chronic hepatitis and hepatocellular carcinoma.

Authors:  Zhu-qing Zhang; Hua Meng; Nan Wang; Li-na Liang; Li-na Liu; Shu-ming Lu; Yong Luan
Journal:  Diagn Pathol       Date:  2014-07-02       Impact factor: 2.644

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