Literature DB >> 24648897

Effects of recombinant human endostatin on the expression of vascular endothelial growth factor in human gastric cancer cell line MGC-803.

Yu-Bin Wang1, Jun-Hong Liu1, Zong-Min Song1.   

Abstract

The present study aimed to explore the effects of recombinant human endostatin, endostar (ES), on the expression of vascular endothelial growth factor (VEGF) in the human gastric cancer cell line MGC-803. The expression of VEGF protein in MGC-803 cells was examined using immunohistochemistry. Subsequent to treatment with various concentrations of ES, the mRNA and VEGF protein expressions were determined in MGC-803 cells. A high level of VEGF protein expression was detected in MGC-803 cells. Subsequent to ES treatment, the mRNA and VEGF protein expressions were significantly decreased in MGC-803 cells (all P<0.05). In conclusion, ES is likely to inhibit the VEGF expression in MGC-803 cells.

Entities:  

Keywords:  gastric cancer; recombinant human endostatin; vascular endothelial growth factor

Year:  2012        PMID： 24648897      PMCID： PMC3956728          DOI： 10.3892/br.2012.3

Source DB:  PubMed          Journal:  Biomed Rep        ISSN： 2049-9434


  6 in total

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Authors:  David M Neskey; Anthony Ambesi; Kevin M Pumiglia; Paula J McKeown-Longo
Journal:  J Exp Clin Cancer Res       Date:  2008-11-04
  6 in total
  3 in total

1.  Autophagy inhibition contributes to Endostar sensitization in esophageal squamous cell carcinoma.

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Journal:  Oncol Lett       Date:  2017-09-21       Impact factor: 2.967

Review 2.  Study Progression of Apelin/APJ Signaling and Apela in Different Types of Cancer.

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Journal:  Front Oncol       Date:  2021-04-12       Impact factor: 6.244

3.  Clinical efficacy of endostar combined with chemotherapy in the treatment of peritoneal carcinomatosis in gastric cancer: results from a retrospective study.

Authors:  Jing Yao; Li Fan; Chunfen Peng; Ai Huang; Tao Liu; Zhenyu Lin; Qin Yang; Tao Zhang; Hong Ma
Journal:  Oncotarget       Date:  2017-08-07
  3 in total

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