Rongying Zhou1, Xian Jiang1. 1. Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China.
Abstract
BACKGROUND: An antibiotic-free, fixed-dose combination gel with adapalene (A) 0.1% and benzoyl peroxide (BPO) 2.5% has been developed for treatment of acne vulgaris. OBJECTIVE: To compare the clinical outcomes of A-BPO combination gel with vehicle gel for treatment or maintenance therapy of patients with acne vulgaris. METHODS: An electronic search of the database PubMed (1966 to September 2012), Embase (1984 to September 2012), and Cochrane Controlled Trials Register (CENTRAL; 3rd Quarter, 2012) was undertaken to identify relevant studies. Main clinical outcomes were success rate, treatment-related adverse events (AEs), AEs leading to discontinuation, satisfaction with the effectiveness, and overall satisfaction. RESULTS: Six studies were finally included in this meta-analysis. The A-BPO group yielded better clinical outcomes regarding the success rate (p<0.00001), satisfaction with the effectiveness of treatment (p=0.005), and overall satisfaction (p=0.005) compared to the vehicle group. The incidence of treatment-related AEs in the A-BPO group was comparable with that of vehicle group (p=0.09), while the A-BPO group was associated with a slightly increase in the incidence of AEs leading to discontinuation when compared with the vehicle group (p=0.02). CONCLUSION: A-BPO combination gel yields better clinical outcomes including success rate, satisfaction with the effectiveness, and overall satisfaction compared to vehicle gel, despite an increased incidence of AEs leading to discontinuation. The A-BPO combination agent most likely contributes to the treatment of moderate acne vulgaris rather than severe acne vulgaris, but it may be useful in maintenance therapy of patients with severe acne vulgaris.
BACKGROUND: An antibiotic-free, fixed-dose combination gel with adapalene (A) 0.1% and benzoyl peroxide (BPO) 2.5% has been developed for treatment of acne vulgaris. OBJECTIVE: To compare the clinical outcomes of A-BPO combination gel with vehicle gel for treatment or maintenance therapy of patients with acne vulgaris. METHODS: An electronic search of the database PubMed (1966 to September 2012), Embase (1984 to September 2012), and Cochrane Controlled Trials Register (CENTRAL; 3rd Quarter, 2012) was undertaken to identify relevant studies. Main clinical outcomes were success rate, treatment-related adverse events (AEs), AEs leading to discontinuation, satisfaction with the effectiveness, and overall satisfaction. RESULTS: Six studies were finally included in this meta-analysis. The A-BPO group yielded better clinical outcomes regarding the success rate (p<0.00001), satisfaction with the effectiveness of treatment (p=0.005), and overall satisfaction (p=0.005) compared to the vehicle group. The incidence of treatment-related AEs in the A-BPO group was comparable with that of vehicle group (p=0.09), while the A-BPO group was associated with a slightly increase in the incidence of AEs leading to discontinuation when compared with the vehicle group (p=0.02). CONCLUSION:A-BPO combination gel yields better clinical outcomes including success rate, satisfaction with the effectiveness, and overall satisfaction compared to vehicle gel, despite an increased incidence of AEs leading to discontinuation. The A-BPO combination agent most likely contributes to the treatment of moderate acne vulgaris rather than severe acne vulgaris, but it may be useful in maintenance therapy of patients with severe acne vulgaris.
Authors: Linda Stein Gold; Alma Cruz; Lawrence Eichenfield; Jerry Tan; Joseph Jorizzo; Nabil Kerrouche; Jean-Charles Dhuin Journal: Cutis Date: 2010-02
Authors: Y Poulin; N P Sanchez; A Bucko; J Fowler; M Jarratt; S Kempers; N Kerrouche; J-C Dhuin; R Kunynetz Journal: Br J Dermatol Date: 2011-05-20 Impact factor: 9.302
Authors: Lawrence E Eichenfield; Joseph L Jorizzo; Thomas Dirschka; Amy Forman Taub; Charles Lynde; Michael Graeber; Nabil Kerrouche Journal: J Drugs Dermatol Date: 2010-11 Impact factor: 2.114
Authors: Jerry Tan; Harald P M Gollnick; Christian Loesche; Y May Ma; Linda Stein Gold Journal: J Dermatolog Treat Date: 2010-07-28 Impact factor: 3.359
Authors: Diane M Thiboutot; Jonathan Weiss; Alicia Bucko; Lawrence Eichenfield; Terry Jones; Scott Clark; Yin Liu; Michael Graeber; Sewon Kang Journal: J Am Acad Dermatol Date: 2007-07-26 Impact factor: 11.527
Authors: Linda Stein Gold; Jerry Tan; Alma Cruz-Santana; Kim Papp; Yves Poulin; Joel Schlessinger; Judi Gidner; Yin Liu; Michael Graeber Journal: Cutis Date: 2009-08
Authors: B Dréno; E Araviiskaia; E Berardesca; G Gontijo; M Sanchez Viera; L F Xiang; R Martin; T Bieber Journal: J Eur Acad Dermatol Venereol Date: 2016-10-13 Impact factor: 6.166