Literature DB >> 24648458

Determinants for membrane association of the hepatitis C virus NS2 protease domain.

Christian M Lange1, Pantxika Bellecave, Viet Loan Dao Thi, Huong T L Tran, François Penin, Darius Moradpour, Jérôme Gouttenoire.   

Abstract

Hepatitis C virus (HCV) nonstructural protein 2 (NS2) is required for HCV polyprotein processing and particle assembly. It comprises an N-terminal membrane domain and a C-terminal, cytosolically oriented protease domain. Here, we demonstrate that the NS2 protease domain itself associates with cellular membranes. A single charged residue in the second α-helix of the NS2 protease domain is required for proper membrane association, NS2 protein stability, and efficient HCV polyprotein processing.

Entities:  

Mesh：

Substances：

Year:  2014        PMID： 24648458      PMCID： PMC4093864          DOI： 10.1128/JVI.00224-14

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  16 in total

1.  Transmission of hepatitis C by intrahepatic inoculation with transcribed RNA.

Authors:  A A Kolykhalov; E V Agapov; K J Blight; K Mihalik; S M Feinstone; C M Rice
Journal:  Science       Date:  1997-07-25       Impact factor: 47.728

Review 2.  The ins and outs of hepatitis C virus entry and assembly.

Authors:  Brett D Lindenbach; Charles M Rice
Journal:  Nat Rev Microbiol       Date:  2013-09-10       Impact factor: 60.633

3.  Hepatitis C virus NS2 protein serves as a scaffold for virus assembly by interacting with both structural and nonstructural proteins.

Authors:  Yinghong Ma; Manu Anantpadma; Jennifer M Timpe; Saravanabalaji Shanmugam; Sher M Singh; Stanley M Lemon; Minkyung Yi
Journal:  J Virol       Date:  2010-10-20       Impact factor: 5.103

4.  Structure of the catalytic domain of the hepatitis C virus NS2-3 protease.

Authors:  Ivo C Lorenz; Joseph Marcotrigiano; Thomas G Dentzer; Charles M Rice
Journal:  Nature       Date:  2006-07-23       Impact factor: 49.962

5.  Identification of a novel determinant for membrane association in hepatitis C virus nonstructural protein 4B.

Authors:  Jérôme Gouttenoire; Valérie Castet; Roland Montserret; Naveen Arora; Vincent Raussens; Jean-Marie Ruysschaert; Eric Diesis; Hubert E Blum; François Penin; Darius Moradpour
Journal:  J Virol       Date:  2009-04-08       Impact factor: 5.103

6.  Structural determinants for membrane association and dynamic organization of the hepatitis C virus NS3-4A complex.

Authors:  Volker Brass; Jan Martin Berke; Roland Montserret; Hubert E Blum; François Penin; Darius Moradpour
Journal:  Proc Natl Acad Sci U S A       Date:  2008-09-17       Impact factor: 11.205

7.  Determinants of the hepatitis C virus nonstructural protein 2 protease domain required for production of infectious virus.

Authors:  Thomas G Dentzer; Ivo C Lorenz; Matthew J Evans; Charles M Rice
Journal:  J Virol       Date:  2009-10-07       Impact factor: 5.103

8.  Complete replication of hepatitis C virus in cell culture.

Authors:  Brett D Lindenbach; Matthew J Evans; Andrew J Syder; Benno Wölk; Timothy L Tellinghuisen; Christopher C Liu; Toshiaki Maruyama; Richard O Hynes; Dennis R Burton; Jane A McKeating; Charles M Rice
Journal:  Science       Date:  2005-06-09       Impact factor: 47.728

9.  Highly permissive cell lines for subgenomic and genomic hepatitis C virus RNA replication.

Authors:  Keril J Blight; Jane A McKeating; Charles M Rice
Journal:  J Virol       Date:  2002-12       Impact factor: 5.103

10.  Structural and functional studies of nonstructural protein 2 of the hepatitis C virus reveal its key role as organizer of virion assembly.

Authors:  Vlastimil Jirasko; Roland Montserret; Ji Young Lee; Jérôme Gouttenoire; Darius Moradpour; Francois Penin; Ralf Bartenschlager
Journal:  PLoS Pathog       Date:  2010-12-16       Impact factor: 6.823
View more
  8 in total

1.  Membrane Topology of Pestiviral Non-Structural Protein 2 and determination of the minimal autoprotease domain.

Authors:  T Walther; J Fellenberg; O Klemens; O Isken; N Tautz
Journal:  J Virol       Date:  2021-03-17       Impact factor: 5.103

2.  NS2 proteins of GB virus B and hepatitis C virus share common protease activities and membrane topologies.

Authors:  Célia Boukadida; Caroline Marnata; Roland Montserret; Lisette Cohen; Brigitte Blumen; Jérôme Gouttenoire; Darius Moradpour; François Penin; Annette Martin
Journal:  J Virol       Date:  2014-04-16       Impact factor: 5.103

3.  Phosphatidylserine-Specific Phospholipase A1 is the Critical Bridge for Hepatitis C Virus Assembly.

Authors:  Qi Yang; Min Guo; Yuan Zhou; Xue Hu; Yun Wang; Chunchen Wu; Min Yang; Rongjuan Pei; Xinwen Chen; Jizheng Chen
Journal:  Virol Sin       Date:  2019-06-03       Impact factor: 4.327

4.  Palmitoylation of Hepatitis C Virus NS2 Regulates Its Subcellular Localization and NS2-NS3 Autocleavage.

Authors:  Ming-Jhan Wu; Saravanabalaji Shanmugam; Christoph Welsch; MinKyung Yi
Journal:  J Virol       Date:  2019-12-12       Impact factor: 5.103

5.  Viral genome wide association study identifies novel hepatitis C virus polymorphisms associated with sofosbuvir treatment failure.

Authors:  David A Smith; Carlota Fernandez-Antunez; Andrea Magri; Rory Bowden; Nimisha Chaturvedi; Jacques Fellay; John McLauchlan; Graham R Foster; William L Irving; Peter Simmonds; Vincent Pedergnana; Santseharay Ramirez; Jens Bukh; Eleanor Barnes; M Azim Ansari
Journal:  Nat Commun       Date:  2021-10-20       Impact factor: 17.694

6.  Production of infectious HCV genotype 1b virus in cell culture using a novel Set of adaptive mutations.

Authors:  Ken-Ichi Mori; Akihiro Matsumoto; Noboru Maki; Yuki Ichikawa; Eiji Tanaka; Shintaro Yagi
Journal:  BMC Microbiol       Date:  2016-09-27       Impact factor: 3.605

7.  NS2 proteases from hepatitis C virus and related hepaciviruses share composite active sites and previously unrecognized intrinsic proteolytic activities.

Authors:  Célia Boukadida; Matthieu Fritz; Brigitte Blumen; Marie-Laure Fogeron; François Penin; Annette Martin
Journal:  PLoS Pathog       Date:  2018-02-07       Impact factor: 6.823

8.  Evolutionary Analysis Provides Insight Into the Origin and Adaptation of HCV.

Authors:  Diego Forni; Rachele Cagliani; Chiara Pontremoli; Uberto Pozzoli; Jacopo Vertemara; Luca De Gioia; Mario Clerici; Manuela Sironi
Journal:  Front Microbiol       Date:  2018-05-01       Impact factor: 5.640
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.