Literature DB >> 2464783

Ligand-independent tyrosine phosphorylation of EGF receptor and the erbB-2/neu proto-oncogene product is induced by hyperosmotic shock.

C R King1, I Borrello, L Porter, P Comoglio, J Schlessinger.   

Abstract

Treatment of intact cells with media containing high concentrations of ionic and non-ionic solutes induced increased tyrosine phosphorylation of the epidermal growth factor (EGF) receptor and the protein product of the erbB-2/neu proto-oncogene. This self phosphorylation occurred in the absence of EGF or other growth factors. High concentrations of solutes did not activate phosphorylation of either isolated EGF receptor or EGF receptor solubilized by non-ionic detergents. No evidence for receptor dimerization was found in response to hyperosmotic shock. Since receptor dimers have been implicated in the EGF-induced activation of EGF receptor, hyperosmotic shock may activate EGF receptor by a different mechanism.

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Year:  1989        PMID： 2464783

Source DB:  PubMed          Journal:  Oncogene        ISSN： 0950-9232            Impact factor:   9.867


  12 in total

1.  Urea signalling to immediate-early gene transcription in renal medullary cells requires transactivation of the epidermal growth factor receptor.

Authors:  Hongyu Zhao; Wei Tian; Hongshi Xu; David M Cohen
Journal:  Biochem J       Date:  2003-03-01       Impact factor: 3.857

2.  An electrostatic engine model for autoinhibition and activation of the epidermal growth factor receptor (EGFR/ErbB) family.

Authors:  Stuart McLaughlin; Steven O Smith; Michael J Hayman; Diana Murray
Journal:  J Gen Physiol       Date:  2005-06-13       Impact factor: 4.086

3.  Overexpression of ERBB2 in human mammary epithelial cells signals inhibition of transcription of the E-cadherin gene.

Authors:  B D'souza; J Taylor-Papadimitriou
Journal:  Proc Natl Acad Sci U S A       Date:  1994-07-19       Impact factor: 11.205

4.  Role of proneuregulin 1 cleavage and human epidermal growth factor receptor activation in hypertonic aquaporin induction.

Authors:  Andreas Herrlich; Virginia Leitch; Landon S King
Journal:  Proc Natl Acad Sci U S A       Date:  2004-10-21       Impact factor: 11.205

5.  MCF-7 breast cancer cells overexpressing transfected c-erbB-2 have an in vitro growth advantage in estrogen-depleted conditions and reduced estrogen-dependence and tamoxifen-sensitivity in vivo.

Authors:  Y Liu; D el-Ashry; D Chen; I Y Ding; F G Kern
Journal:  Breast Cancer Res Treat       Date:  1995-05       Impact factor: 4.872

6.  Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family.

Authors:  G D Plowman; J M Culouscou; G S Whitney; J M Green; G W Carlton; L Foy; M G Neubauer; M Shoyab
Journal:  Proc Natl Acad Sci U S A       Date:  1993-03-01       Impact factor: 11.205

7.  EGFR juxtamembrane domain, membranes, and calmodulin: kinetics of their interaction.

Authors:  Parijat Sengupta; Eran Bosis; Esther Nachliel; Menachem Gutman; Steven O Smith; Gyöngyi Mihályné; Irina Zaitseva; Stuart McLaughlin
Journal:  Biophys J       Date:  2009-06-17       Impact factor: 4.033

8.  Oxidative and osmotic stress signaling in tumor cells is mediated by ADAM proteases and heparin-binding epidermal growth factor.

Authors:  Oliver M Fischer; Stefan Hart; Andreas Gschwind; Norbert Prenzel; Axel Ullrich
Journal:  Mol Cell Biol       Date:  2004-06       Impact factor: 4.272

Review 9.  Employment of the epidermal growth factor receptor in growth factor-independent signaling pathways.

Authors:  G Carpenter
Journal:  J Cell Biol       Date:  1999-08-23       Impact factor: 10.539

10.  Cell-type specific interaction of Neu differentiation factor (NDF/heregulin) with Neu/HER-2 suggests complex ligand-receptor relationships.

Authors:  E Peles; R Ben-Levy; E Tzahar; N Liu; D Wen; Y Yarden
Journal:  EMBO J       Date:  1993-03       Impact factor: 11.598
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