Literature DB >> 24646940

Anti-CXCL13 antibody can inhibit the formation of gastric lymphoid follicles induced by Helicobacter infection.

K Yamamoto1, S Nishiumi1, L Yang1, E Klimatcheva2, T Pandina2, S Takahashi3, H Matsui4, M Nakamura5, M Zauderer2, M Yoshida6, T Azuma1.   

Abstract

Helicobacter suis infects the stomachs of both animals and humans, and can induce gastric mucosa-associated lymphoid tissue (MALT) lymphomas. It is known that CXC chemokine ligand 13 (CXCL13) is highly expressed in the Helicobacter-infected mice and gastric MALT lymphoma patients, but the pathway that links the activation of CXCL13 and the formation of gastric MALT lymphomas remains unclear. In this study, we examined whether CXCL13 neutralization would interfere with the formation of gastric lymphoid follicles including B cells, CD4+T cells, dendritic cells (DCs), and follicular DCs (FDCs) in germinal centers to determine the role of CXCL13 in the formation of B-cell aggregates after H. suis infection. Moreover, the expression of genes associated with the lymphoid follicle formation was also effectively suppressed by anti-CXCL13 antibody treatment. These results suggest that the upregulation of CXCL13 has an important role in the development of gastric MALT lymphomas and highlight the potential of anti-CXCL13 antibody for protection against Helicobacter-induced gastric diseases.

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Year:  2014        PMID： 24646940     DOI： 10.1038/mi.2014.14

Source DB:  PubMed          Journal:  Mucosal Immunol        ISSN： 1933-0219            Impact factor:   7.313


  56 in total

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2.  Prevalence of 'Candidatus Helicobacter suis' in pigs of different ages.

Authors:  A Hellemans; K Chiers; M De Bock; A Decostere; F Haesebrouck; R Ducatelle; D Maes
Journal:  Vet Rec       Date:  2007-08-11       Impact factor: 2.695

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Authors:  A Morgner; N Lehn; L P Andersen; C Thiede; M Bennedsen; K Trebesius; B Neubauer; A Neubauer; M Stolte; E Bayerdörffer
Journal:  Gastroenterology       Date:  2000-05       Impact factor: 22.682

4.  Two distinctive pathways for recruitment of naive and primed IgM+ B cells to the gut lamina propria.

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5.  B cell attracting chemokine 1 (CXCL13) and its receptor CXCR5 are expressed in normal and aberrant gut associated lymphoid tissue.

Authors:  H S Carlsen; E S Baekkevold; F-E Johansen; G Haraldsen; P Brandtzaeg
Journal:  Gut       Date:  2002-09       Impact factor: 23.059

6.  Gastric lesions and immune responses caused by long-term infection with Helicobacter heilmannii in C57BL/6 mice.

Authors:  Jong-Hwan Park; S H Seok; M W Baek; H Y Lee; D J Kim; Jae-Hak Park
Journal:  J Comp Pathol       Date:  2008-09-26       Impact factor: 1.311

7.  Intracerebral expression of CXCL13 and BAFF is accompanied by formation of lymphoid follicle-like structures in the meninges of mice with relapsing experimental autoimmune encephalomyelitis.

Authors:  Roberta Magliozzi; Sandra Columba-Cabezas; Barbara Serafini; Francesca Aloisi
Journal:  J Neuroimmunol       Date:  2004-03       Impact factor: 3.478

8.  Prevalence of lymphoid follicles and aggregates in Helicobacter pylori gastritis in antral and body mucosa.

Authors:  S Eidt; M Stolte
Journal:  J Clin Pathol       Date:  1993-09       Impact factor: 3.411

Review 9.  Lymphoid neogenesis in chronic inflammatory diseases.

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Review 10.  Gastric helicobacters in domestic animals and nonhuman primates and their significance for human health.

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  16 in total

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Authors:  Balázs Koscsó; Sravya Kurapati; Richard R Rodrigues; Jelena Nedjic; Kavitha Gowda; Changsik Shin; Chetna Soni; Azree Zaffran Ashraf; Indira Purushothaman; Maryknoll Palisoc; Sulei Xu; Haoyu Sun; Sathi Babu Chodisetti; Eugene Lin; Matthias Mack; Yuka Imamura Kawasawa; Pingnian He; Ziaur S M Rahman; Iannis Aifantis; Natalia Shulzhenko; Andrey Morgun; Milena Bogunovic
Journal:  Sci Immunol       Date:  2020-04-10

2.  Targeting CXCL13 During Neuroinflammation.

Authors:  Amanda K Huber; David N Irani
Journal:  Adv Neuroimmune Biol       Date:  2015-11-13

3.  CXCL13 Signaling in the Tumor Microenvironment.

Authors:  Muzammal Hussain; Jinsong Liu; Gui-Zhen Wang; Guang-Biao Zhou
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

4.  CXCL13-producing TFH cells link immune suppression and adaptive memory in human breast cancer.

Authors:  Chunyan Gu-Trantien; Edoardo Migliori; Laurence Buisseret; Alexandre de Wind; Sylvain Brohée; Soizic Garaud; Grégory Noël; Vu Luan Dang Chi; Jean-Nicolas Lodewyckx; Céline Naveaux; Hugues Duvillier; Stanislas Goriely; Denis Larsimont; Karen Willard-Gallo
Journal:  JCI Insight       Date:  2017-06-02

5.  Interferon-γ-producing B cells induce the formation of gastric lymphoid follicles after Helicobacter suis infection.

Authors:  L Yang; K Yamamoto; S Nishiumi; M Nakamura; H Matsui; S Takahashi; T Dohi; T Okada; K Kakimoto; N Hoshi; M Yoshida; T Azuma
Journal:  Mucosal Immunol       Date:  2014-07-30       Impact factor: 7.313

6.  Gastric LTi cells promote lymphoid follicle formation but are limited by IRAK-M and do not alter microbial growth.

Authors:  J Shiu; M B Piazuelo; H Ding; S J Czinn; M L Drakes; A Banerjee; N Basappa; K S Kobayashi; W F Fricke; T G Blanchard
Journal:  Mucosal Immunol       Date:  2015-01-21       Impact factor: 7.313

7.  Role of γ-glutamyltranspeptidase in the pathogenesis of Helicobacter suis and Helicobacter pylori infections.

Authors:  Guangzhi Zhang; Richard Ducatelle; Ellen De Bruyne; Myrthe Joosten; Iris Bosschem; Annemieke Smet; Freddy Haesebrouck; Bram Flahou
Journal:  Vet Res       Date:  2015-03-13       Impact factor: 3.683

8.  Type-I interferons suppress microglial production of the lymphoid chemokine, CXCL13.

Authors:  Nilufer Esen; Emily K Rainey-Barger; Amanda K Huber; Pennelope K Blakely; David N Irani
Journal:  Glia       Date:  2014-05-14       Impact factor: 7.452

9.  Regulatory T cells may participate in Helicobacter pylori persistence in gastric MALT lymphoma: lessons from an animal model.

Authors:  Amandine Marine Laur; Pauline Floch; Lucie Chambonnier; Lucie Benejat; Victoria Korolik; Alban Giese; Pierre Dubus; Francis Mégraud; Antonio Bandeira; Philippe Lehours
Journal:  Oncotarget       Date:  2016-01-19

Review 10.  Ectopic Tertiary Lymphoid Tissue in Inflammatory Bowel Disease: Protective or Provocateur?

Authors:  Eóin N McNamee; Jesús Rivera-Nieves
Journal:  Front Immunol       Date:  2016-08-16       Impact factor: 7.561
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