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Literature DB >> 24646669

Microglial phagocytosis of live neurons.

Abstract

Microglia, the brain's professional phagocytes, can remove dead and dying neurons as well as synapses and the processes of live neurons. However, we and others have recently shown that microglia can also execute neuronal death by phagocytosing stressed-but-viable neurons - a process that we have termed phagoptosis. In this Progress article, we discuss evidence suggesting that phagoptosis may contribute to neuronal loss during brain development, inflammation, ischaemia and neurodegeneration.

Entities: Chemical

Mesh：

Year: 2014 PMID： 24646669 DOI： 10.1038/nrn3710

Source DB: PubMed Journal: Nat Rev Neurosci ISSN： 1471-003X Impact factor: 34.870

76 in total

Review 1. Eaten alive! Cell death by primary phagocytosis: 'phagoptosis'.

Authors: Guy C Brown; Jonas J Neher
Journal: Trends Biochem Sci Date: 2012-06-07 Impact factor: 13.807

2. Atp8a1 deficiency is associated with phosphatidylserine externalization in hippocampus and delayed hippocampus-dependent learning.

Authors: Kelly Levano; Vineet Punia; Michael Raghunath; Priya Ranjan Debata; Gina Marie Curcio; Amit Mogha; Sudarshana Purkayastha; Dan McCloskey; Jimmie Fata; Probal Banerjee
Journal: J Neurochem Date: 2011-12-02 Impact factor: 5.372

3. An angiogenic inhibitor, cyclic RGDfV, attenuates MPTP-induced dopamine neuron toxicity.

Authors: Aditiben Patel; Giuseppe V Toia; Kalea Colletta; Brinda Desai Bradaric; Paul M Carvey; Bill Hendey
Journal: Exp Neurol Date: 2011-06-15 Impact factor: 5.330

4. Identification of a factor that links apoptotic cells to phagocytes.

Authors: Rikinari Hanayama; Masato Tanaka; Keiko Miwa; Azusa Shinohara; Akihiro Iwamatsu; Shigekazu Nagata
Journal: Nature Date: 2002-05-09 Impact factor: 49.962

5. Annexin A1: a central player in the anti-inflammatory and neuroprotective role of microglia.

Authors: Simon McArthur; Enrico Cristante; Mario Paterno; Helen Christian; Federico Roncaroli; Glenda E Gillies; Egle Solito
Journal: J Immunol Date: 2010-10-20 Impact factor: 5.422

6. Engulfment genes cooperate with ced-3 to promote cell death in Caenorhabditis elegans.

Authors: D J Hoeppner; M O Hengartner; R Schnabel
Journal: Nature Date: 2001-07-12 Impact factor: 49.962

7. Neuromelanin activates microglia and induces degeneration of dopaminergic neurons: implications for progression of Parkinson's disease.

Authors: Wei Zhang; Kester Phillips; Albert R Wielgus; Jie Liu; Alberto Albertini; Fabio A Zucca; Rudolph Faust; Steven Y Qian; David S Miller; Colin F Chignell; Belinda Wilson; Vernice Jackson-Lewis; Serge Przedborski; Danielle Joset; John Loike; Jau-Shyong Hong; David Sulzer; Luigi Zecca
Journal: Neurotox Res Date: 2009-12-03 Impact factor: 3.911

8. Mapping and kinetics of microglia/neuron cell-to-cell contacts in the 6-OHDA murine model of Parkinson's disease.

Authors: Angélique Virgone-Carlotta; Josselin Uhlrich; Muhammad Numan Akram; Denis Ressnikoff; Fabrice Chrétien; Chantal Domenget; Romain Gherardi; Geneviève Despars; Pierre Jurdic; Jérôme Honnorat; Serge Nataf; Monique Touret
Journal: Glia Date: 2013-07-25 Impact factor: 7.452

9. Relationship between microglial activation and dopaminergic neuronal loss in the substantia nigra: a time course study in a 6-hydroxydopamine model of Parkinson's disease.

Authors: Lilia Marinova-Mutafchieva; Mona Sadeghian; Lauren Broom; John B Davis; Andrew D Medhurst; David T Dexter
Journal: J Neurochem Date: 2009-06-22 Impact factor: 5.372

10. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.

Authors: Adam C Naj; Gyungah Jun; Gary W Beecham; Li-San Wang; Badri Narayan Vardarajan; Jacqueline Buros; Paul J Gallins; Joseph D Buxbaum; Gail P Jarvik; Paul K Crane; Eric B Larson; Thomas D Bird; Bradley F Boeve; Neill R Graff-Radford; Philip L De Jager; Denis Evans; Julie A Schneider; Minerva M Carrasquillo; Nilufer Ertekin-Taner; Steven G Younkin; Carlos Cruchaga; John S K Kauwe; Petra Nowotny; Patricia Kramer; John Hardy; Matthew J Huentelman; Amanda J Myers; Michael M Barmada; F Yesim Demirci; Clinton T Baldwin; Robert C Green; Ekaterina Rogaeva; Peter St George-Hyslop; Steven E Arnold; Robert Barber; Thomas Beach; Eileen H Bigio; James D Bowen; Adam Boxer; James R Burke; Nigel J Cairns; Chris S Carlson; Regina M Carney; Steven L Carroll; Helena C Chui; David G Clark; Jason Corneveaux; Carl W Cotman; Jeffrey L Cummings; Charles DeCarli; Steven T DeKosky; Ramon Diaz-Arrastia; Malcolm Dick; Dennis W Dickson; William G Ellis; Kelley M Faber; Kenneth B Fallon; Martin R Farlow; Steven Ferris; Matthew P Frosch; Douglas R Galasko; Mary Ganguli; Marla Gearing; Daniel H Geschwind; Bernardino Ghetti; John R Gilbert; Sid Gilman; Bruno Giordani; Jonathan D Glass; John H Growdon; Ronald L Hamilton; Lindy E Harrell; Elizabeth Head; Lawrence S Honig; Christine M Hulette; Bradley T Hyman; Gregory A Jicha; Lee-Way Jin; Nancy Johnson; Jason Karlawish; Anna Karydas; Jeffrey A Kaye; Ronald Kim; Edward H Koo; Neil W Kowall; James J Lah; Allan I Levey; Andrew P Lieberman; Oscar L Lopez; Wendy J Mack; Daniel C Marson; Frank Martiniuk; Deborah C Mash; Eliezer Masliah; Wayne C McCormick; Susan M McCurry; Andrew N McDavid; Ann C McKee; Marsel Mesulam; Bruce L Miller; Carol A Miller; Joshua W Miller; Joseph E Parisi; Daniel P Perl; Elaine Peskind; Ronald C Petersen; Wayne W Poon; Joseph F Quinn; Ruchita A Rajbhandary; Murray Raskind; Barry Reisberg; John M Ringman; Erik D Roberson; Roger N Rosenberg; Mary Sano; Lon S Schneider; William Seeley; Michael L Shelanski; Michael A Slifer; Charles D Smith; Joshua A Sonnen; Salvatore Spina; Robert A Stern; Rudolph E Tanzi; John Q Trojanowski; Juan C Troncoso; Vivianna M Van Deerlin; Harry V Vinters; Jean Paul Vonsattel; Sandra Weintraub; Kathleen A Welsh-Bohmer; Jennifer Williamson; Randall L Woltjer; Laura B Cantwell; Beth A Dombroski; Duane Beekly; Kathryn L Lunetta; Eden R Martin; M Ilyas Kamboh; Andrew J Saykin; Eric M Reiman; David A Bennett; John C Morris; Thomas J Montine; Alison M Goate; Deborah Blacker; Debby W Tsuang; Hakon Hakonarson; Walter A Kukull; Tatiana M Foroud; Jonathan L Haines; Richard Mayeux; Margaret A Pericak-Vance; Lindsay A Farrer; Gerard D Schellenberg
Journal: Nat Genet Date: 2011-04-03 Impact factor: 38.330

312 in total

1. Post-conversion sialylation of prions in lymphoid tissues.

Authors: Saurabh Srivastava; Natallia Makarava; Elizaveta Katorcha; Regina Savtchenko; Reinhard Brossmer; Ilia V Baskakov
Journal: Proc Natl Acad Sci U S A Date: 2015-11-16 Impact factor: 11.205

Review 2. The Role of Inflammatory Mediators in the Pathogenesis of Alzheimer's Disease.

Authors: Gholamreza Azizi; Shadi S Navabi; Ahmed Al-Shukaili; Mir H Seyedzadeh; Reza Yazdani; Abbas Mirshafiey
Journal: Sultan Qaboos Univ Med J Date: 2015-08-24

Review 3. Inflammation in Alzheimer's disease: Lessons learned from microglia-depletion models.

Authors: Elizabeth E Spangenberg; Kim N Green
Journal: Brain Behav Immun Date: 2016-07-06 Impact factor: 7.217

4. Proliferating SPP1/MERTK-expressing macrophages in idiopathic pulmonary fibrosis.

Authors: Christina Morse; Tracy Tabib; John Sembrat; Kristina L Buschur; Humberto Trejo Bittar; Eleanor Valenzi; Yale Jiang; Daniel J Kass; Kevin Gibson; Wei Chen; Ana Mora; Panayiotis V Benos; Mauricio Rojas; Robert Lafyatis
Journal: Eur Respir J Date: 2019-08-22 Impact factor: 16.671