Literature DB >> 2464653

Expression of pertussis toxin correlates with pathogenesis in Bordetella species.

D Monack1, J J Munoz, M G Peacock, W J Black, S Falkow.   

Abstract

Pertussis toxin is a principal determinant of virulence produced by Bordetella pertussis in the disease whooping cough and is the primary toxinogenic component of the pertussis vaccine. This toxin is not produced by the closely related species Bordetella parapertussis. Toxinogenic strains of B. parapertussis were constructed by the conjugative introduction of cloned pertussis toxin genes. These and analogous toxinogenic and nontoxinogenic strains of B. pertussis were assayed for their toxicity and reactogenic activities. Expression of active toxin by either Bordetella sp. correlated with the induction of leukocytosis, anaphylaxis, and histamine sensitivity.

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Year:  1989        PMID： 2464653     DOI： 10.1093/infdis/159.2.205

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  12 in total

1.  Subcellular localization and immunological detection of proteins encoded by the vir locus of Bordetella pertussis.

Authors:  S Stibitz; M S Yang
Journal:  J Bacteriol       Date:  1991-07       Impact factor: 3.490

2.  Identification of linear B-cell determinants of pertussis toxin associated with the receptor recognition site of the S3 subunit.

Authors:  M A Schmidt; B Raupach; M Szulczynski; J Marzillier
Journal:  Infect Immun       Date:  1991-04       Impact factor: 3.441

3.  Site-specific mutagenesis of the catalytic subunit of cholera toxin: substituting lysine for arginine 7 causes loss of activity.

Authors:  W N Burnette; V L Mar; B W Platler; J D Schlotterbeck; M D McGinley; K S Stoney; M F Rohde; H R Kaslow
Journal:  Infect Immun       Date:  1991-11       Impact factor: 3.441

4.  Inhibition of pertussis toxin binding to model receptors by antipeptide antibodies directed at an antigenic domain of the S2 subunit.

Authors:  M A Schmidt; W Schmidt
Journal:  Infect Immun       Date:  1989-12       Impact factor: 3.441

5.  Identification of B-cell epitopes on the S4 subunit of pertussis toxin.

Authors:  P H Ibsen; A Holm; J W Petersen; C E Olsen; I Heron
Journal:  Infect Immun       Date:  1993-06       Impact factor: 3.441

6.  Intranasal interleukin-12 therapy inhibits Mycoplasma pneumoniae clearance and sustains airway obstruction in murine pneumonia.

Authors:  C M Salvatore; M Fonseca-Aten; K Katz-Gaynor; A M Gomez; R D Hardy
Journal:  Infect Immun       Date:  2007-11-26       Impact factor: 3.441

7.  Bordetella pertussis and Bordetella parapertussis: two immunologically distinct species.

Authors:  N Khelef; B Danve; M J Quentin-Millet; N Guiso
Journal:  Infect Immun       Date:  1993-02       Impact factor: 3.441

8.  Role of pertussis toxin in causing symptoms of Bordetella parapertussis infection.

Authors:  C H Wirsing von König; H Finger
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1994-06       Impact factor: 3.267

9.  Sequential activation and environmental regulation of virulence genes in Bordetella pertussis.

Authors:  V Scarlato; B Aricò; A Prugnola; R Rappuoli
Journal:  EMBO J       Date:  1991-12       Impact factor: 11.598

10.  Construction of Bordetella pertussis strains with enhanced production of genetically-inactivated Pertussis Toxin and Pertactin by unmarked allelic exchange.

Authors:  Wasin Buasri; Attawut Impoolsup; Chuenchit Boonchird; Anocha Luengchaichawange; Pannipa Prompiboon; Jean Petre; Watanalai Panbangred
Journal:  BMC Microbiol       Date:  2012-04-23       Impact factor: 3.605
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