Literature DB >> 2464571

Transforming growth factor-beta inhibits cellular adenylate cyclase activity in cultured human arterial endothelial cells.

H Mioh1, J K Chen.   

Abstract

Stimulation of human arterial endothelial cells with heparin-binding growth factor-1 (HBGF-1) resulted in a 40% to 60% increase in the cellular adenylate cyclase activity and intracellular cAMP content. The stimulatory effect of HBGF-1 was effectively suppressed by pretreating the cells with transforming growth factor-beta (TGF-beta), an endothelial cell growth inhibitor. The inhibition of the adenylate cyclase activity precedes growth inhibition by at least 24 h. The half maximal inhibitory dose was calculated to be 0.2 ng/ml for the inhibition of both cyclase activity and cell growth. The possible role of the adenylate cyclase suppression in growth inhibition by TGF-beta is discussed.

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Year:  1989        PMID： 2464571     DOI： 10.1007/bf02624418

Source DB:  PubMed          Journal:  In Vitro Cell Dev Biol        ISSN： 0883-8364


  14 in total

1.  Reversible inhibition of normal human prokeratinocyte proliferation by type beta transforming growth factor-growth inhibitor in serum-free medium.

Authors:  G D Shipley; M R Pittelkow; J J Wille; R E Scott; H L Moses
Journal:  Cancer Res       Date:  1986-04       Impact factor: 12.701

Review 2.  G proteins: transducers of receptor-generated signals.

Authors:  A G Gilman
Journal:  Annu Rev Biochem       Date:  1987       Impact factor: 23.643

3.  Isolation and characterization of different molecular and chromatographic forms of heparin-binding growth factor 1 from bovine brain.

Authors:  W L McKeehan; J W Crabb
Journal:  Anal Biochem       Date:  1987-08-01       Impact factor: 3.365

4.  Acidic heparin binding growth factor transiently activates adenylate cyclase activity in human adult arterial smooth muscle cells.

Authors:  H Mioh; J K Chen
Journal:  Biochem Biophys Res Commun       Date:  1987-07-31       Impact factor: 3.575

5.  Inhibition of endothelial cell proliferation by type beta-transforming growth factor: interactions with acidic and basic fibroblast growth factors.

Authors:  A Baird; T Durkin
Journal:  Biochem Biophys Res Commun       Date:  1986-07-16       Impact factor: 3.575

6.  Role of lipoproteins in growth of human adult arterial endothelial and smooth muscle cells in low lipoprotein-deficient serum.

Authors:  J K Chen; H Hoshi; D B McClure; W L McKeehan
Journal:  J Cell Physiol       Date:  1986-11       Impact factor: 6.384

7.  DNA synthesis in rat hepatocytes: inhibition by a platelet factor and stimulation by an endogenous factor.

Authors:  I Hayashi; B I Carr
Journal:  J Cell Physiol       Date:  1985-10       Impact factor: 6.384

8.  Calcium, magnesium, and serum factors in multiplication of normal and transformed human lung fibroblasts.

Authors:  W L McKeehan; K A McKeehan
Journal:  In Vitro       Date:  1980-06

9.  TGF-beta inhibition of endothelial cell proliferation: alteration of EGF binding and EGF-induced growth-regulatory (competence) gene expression.

Authors:  K Takehara; E C LeRoy; G R Grotendorst
Journal:  Cell       Date:  1987-05-08       Impact factor: 41.582

10.  The antiproliferative effect of type beta transforming growth factor occurs at a level distal from receptors for growth-activating factors.

Authors:  B Like; J Massagué
Journal:  J Biol Chem       Date:  1986-10-15       Impact factor: 5.157
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  2 in total

1.  Modulation of response to adenosine in vascular smooth muscle cells cultured in defined medium.

Authors:  Y M Xiong; S Z Xu; L L Slakey
Journal:  In Vitro Cell Dev Biol       Date:  1991-05

2.  Transformed human bronchial epithelial cells (BEAS-2B) alter the growth and morphology of normal human bronchial epithelial cells in vitro.

Authors:  C D Albright; R T Jones; E A Hudson; J A Fontana; B F Trump; J H Resau
Journal:  Cell Biol Toxicol       Date:  1990-10       Impact factor: 6.691
  2 in total

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