Literature DB >> 2464415

Psychotropic drugs block voltage-gated ion channels in neuroblastoma cells.

N Ogata1, M Yoshii, T Narahashi.   

Abstract

Effects of neuroleptics and tricyclic antidepressants on voltage-gated ion channels were investigated in the neuroblastoma cell line N1E-115 using the whole cell variation of patch electrode voltage-clamp techniques. Imipramine, chlorpromazine and haloperidol in micromolar concentrations blocked sodium, calcium and potassium channel currents in a reversible and concentration-dependent manner. The order of potency was chlorpromazine greater than imipramine greater than haloperidol. These direct blocking actions on neuronal ion channels might play a role in clinical effects of these drugs.

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Year:  1989        PMID： 2464415     DOI： 10.1016/0006-8993(89)91546-1

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  21 in total

Review 1.  Antidepressants as analgesics: an overview of central and peripheral mechanisms of action.

Authors:  J Sawynok; M J Esser; A R Reid
Journal:  J Psychiatry Neurosci       Date:  2001-01       Impact factor: 6.186

Review 2.  Psychopharmacological properties of calcium channel inhibitors.

Authors:  O Pucilowski
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530

3.  Parathyroid hormone selectively inhibits L-type calcium channels in single vascular smooth muscle cells of the rat.

Authors:  R Wang; E Karpinski; P K Pang
Journal:  J Physiol       Date:  1991-09       Impact factor: 5.182

4.  Effect fingerprints of antipsychotic drugs on neural networks in vitro.

Authors:  Philipp Görtz; Uwe Henning; Stephan Theiss; Christian Lange-Asschenfeldt
Journal:  J Neural Transm (Vienna)       Date:  2019-07-18       Impact factor: 3.575

5.  The effects of neuroleptics on the GABA-induced Cl- current in rat dorsal root ganglion neurons: differences between some neuroleptics.

Authors:  Kenjiro Yokota; Hideharu Tatebayashi; Tadashi Matsuo; Takashi Shoge; Haruhiko Motomura; Toshiyuki Matsuno; Akira Fukuda; Nobutada Tashiro
Journal:  Br J Pharmacol       Date:  2002-03       Impact factor: 8.739

6.  Local Anesthetics and Antipsychotic Phenothiazines Interact Nonspecifically with Membranes and Inhibit Hexose Transporters in Yeast.

Authors:  Yukifumi Uesono; Akio Toh-e; Yoshiko Kikuchi; Tomoyuki Araki; Takushi Hachiya; Chihiro K Watanabe; Ko Noguchi; Ichiro Terashima
Journal:  Genetics       Date:  2016-01-12       Impact factor: 4.562

7.  High concentrations of tricyclic antidepressants increase intracellular Ca2+ in cultured neural cells.

Authors:  P G Joshi; A Singh; B Ravichandra
Journal:  Neurochem Res       Date:  1999-03       Impact factor: 3.996

8.  Modulation of sodium current kinetics by chlorpromazine in freshly-isolated striatal neurones of the adult guinea-pig.

Authors:  N Ogata; H Tatebayashi
Journal:  Br J Pharmacol       Date:  1989-12       Impact factor: 8.739

9.  Effect of some stereoisomeric tricyclic antidepressants on 45Ca uptake in synaptosomes from rat hippocampus.

Authors:  G Beauchamp; P A Lavoie; R Elie
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

10.  Block of potassium currents in rat isolated sympathetic neurones by tricyclic antidepressants and structurally related compounds.

Authors:  J R Wooltorton; A Mathie
Journal:  Br J Pharmacol       Date:  1993-11       Impact factor: 8.739
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