Alistair J A Duff1, Janice Abbott2, Carolyn Cowperthwaite3, Clare Sumner4, Margaret A Hurley5, Alexandra Quittner6. 1. Regional Paediatric CF Unit, Leeds Teaching Hospitals NHS Trust, Ward 25 A Floor, Clarendon Wing, Leeds General Infirmary, Leeds LS2 9NS, UK; Institute of Health Sciences, School of Medicine, University of Leeds, Leeds, UK. Electronic address: alistair.duff@leedsth.nhs.uk. 2. School of Psychology, University of Central Lancashire, Preston, UK. Electronic address: jabbott@uclan.ac.uk. 3. Adult Cystic Fibrosis Unit, Liverpool Heart & Chest Hospital, Liverpool, UK. Electronic address: Carolyn.Cowperthwaite@lhch.nhs.uk. 4. Adult Cystic Fibrosis Unit, Liverpool Heart & Chest Hospital, Liverpool, UK. Electronic address: Clare.Sumner@lhch.nhs.uk. 5. School of Health, University of Central Lancashire, Preston, UK. Electronic address: MAHurley@uclan.ac.uk. 6. Child Division, University of Miami, Miami, USA. Electronic address: aquittner@miami.edu.
Abstract
BACKGROUND: The International Depression/anxiety Epidemiological Study (TIDES) in the UK aimed: (i) to establish the prevalence of anxiety and depression amongst people with CF compared to a normative sample; (ii) to establish the association between mood, demographic and clinical variables; and (iii) to provide guidance for specialist-referral decision-making. METHODS: Patients (≥12years) completed the Hospital Anxiety and Depression Scale (HADS). CF-HADS scores, expressed as percentiles, were compared with a normative sample. Multiple-regression analysis explored associations between demographic, clinical and mood variables. RESULTS: Thirty-nine CF centres recruited 2065 patients. Adults with CF were similar in terms of anxiety and depression to the general population. Adolescents with CF were less anxious and depressed. For adult patients, older age, unemployment for health reasons and poor lung function were associated with disordered mood. Gender-specific CF-percentile scores were calculated. CONCLUSION: Surveillance, with attention to gender and risk factors is advocated. This work provides unique benchmark scores to aid referral decision-making.
BACKGROUND: The International Depression/anxiety Epidemiological Study (TIDES) in the UK aimed: (i) to establish the prevalence of anxiety and depression amongst people with CF compared to a normative sample; (ii) to establish the association between mood, demographic and clinical variables; and (iii) to provide guidance for specialist-referral decision-making. METHODS:Patients (≥12years) completed the Hospital Anxiety and Depression Scale (HADS). CF-HADS scores, expressed as percentiles, were compared with a normative sample. Multiple-regression analysis explored associations between demographic, clinical and mood variables. RESULTS: Thirty-nine CF centres recruited 2065 patients. Adults with CF were similar in terms of anxiety and depression to the general population. Adolescents with CF were less anxious and depressed. For adult patients, older age, unemployment for health reasons and poor lung function were associated with disordered mood. Gender-specific CF-percentile scores were calculated. CONCLUSION: Surveillance, with attention to gender and risk factors is advocated. This work provides unique benchmark scores to aid referral decision-making.
Authors: Lena Backström-Eriksson; Kimmo Sorjonen; Agneta Bergsten-Brucefors; Lena Hjelte; Bo Melin Journal: BMC Pulm Med Date: 2015-10-14 Impact factor: 3.317
Authors: Jennifer Cronly; Alistair J Duff; Kristin A Riekert; Ivan J Perry; Anthony P Fitzgerald; Aine Horgan; Elaine Lehane; Barbara Howe; Muireann Ni Chroinin; Eileen Savage Journal: BMJ Open Date: 2018-01-21 Impact factor: 2.692
Authors: Samantha Ellis; Catherine Rang; Tom Kotsimbos; Dominic Keating; Felicity Finlayson; Richard Stark; Dominic Thyagarajan; John Wilson Journal: BMJ Open Respir Res Date: 2019-08-09