Zisis Kratiras1, Charalampos Konstantinidis2, Konstantinos Skriapas1. 1. Department of Urology, ″Koutlibanio″ General Hospital of Larisa, Larissa, Greece. 2. Department of Urology and Neuro-urology, National Rehabilitation Center, Athens, Greece.
Abstract
OBJECTIVES: To review the literature and present new data of continuous androgen deprivation therapy (ADT) vs intermittent androgen deprivation (IAD) as therapies for prostate cancer in terms of survival and quality of life and clarify practical issues in the use of IAD. MATERIALS AND METHODS: We conducted a systematic search on Medline and Embase databases using ″prostatic neoplasm″ and ″intermittent androgen deprivation″ as search terms. We reviewed meta-analyses, randomised controlled trials, reviews, clinical trials and practise guidelines written in English from 2000 and onwards until 01/04/2013. Ten randomized controlled trials were identified. Seven of them published extensive data and results randomizing 4675 patients to IAD versus CAD. Data from the other three randomized trials were limited. RESULTS: Over the last years studies confirmed that IAD is an effective alternative approach to hormonal deprivation providing simultaneously several potential benefits in terms of quality of life and cost effectiveness. Thus, in patients with non metastatic, advanced prostate cancer IAD could be used as standard treatment, while in metastatic prostate cancer IAD role still remains ambiguous. CONCLUSIONS: Nowadays, revaluation of the gold standard of ADT in advanced prostate cancer appears essential. Recent data established that IAD should no longer be consi¬dered as investigational, since its effectiveness has been proven, especially in patients suffering from non-metastatic advanced prostate cancer.
OBJECTIVES: To review the literature and present new data of continuous androgen deprivation therapy (ADT) vs intermittent androgen deprivation (IAD) as therapies for prostate cancer in terms of survival and quality of life and clarify practical issues in the use of IAD. MATERIALS AND METHODS: We conducted a systematic search on Medline and Embase databases using ″prostatic neoplasm″ and ″intermittent androgen deprivation″ as search terms. We reviewed meta-analyses, randomised controlled trials, reviews, clinical trials and practise guidelines written in English from 2000 and onwards until 01/04/2013. Ten randomized controlled trials were identified. Seven of them published extensive data and results randomizing 4675 patients to IAD versus CAD. Data from the other three randomized trials were limited. RESULTS: Over the last years studies confirmed that IAD is an effective alternative approach to hormonal deprivation providing simultaneously several potential benefits in terms of quality of life and cost effectiveness. Thus, in patients with non metastatic, advanced prostate cancerIAD could be used as standard treatment, while in metastatic prostate cancer IAD role still remains ambiguous. CONCLUSIONS: Nowadays, revaluation of the gold standard of ADT in advanced prostate cancer appears essential. Recent data established that IAD should no longer be consi¬dered as investigational, since its effectiveness has been proven, especially in patients suffering from non-metastatic advanced prostate cancer.
Authors: Laura E Pascal; Khalid Z Masoodi; Katherine J O'Malley; Daniel Shevrin; Jeffrey R Gingrich; Rahul A Parikh; Zhou Wang Journal: J Urol Date: 2014-10-31 Impact factor: 7.450
Authors: Xingcheng Lin; Prakash Kulkarni; Federico Bocci; Nicholas P Schafer; Susmita Roy; Min-Yeh Tsai; Yanan He; Yihong Chen; Krithika Rajagopalan; Steven M Mooney; Yu Zeng; Keith Weninger; Alex Grishaev; José N Onuchic; Herbert Levine; Peter G Wolynes; Ravi Salgia; Govindan Rangarajan; Vladimir Uversky; John Orban; Mohit Kumar Jolly Journal: Biomolecules Date: 2019-02-22