Dan He1, Maosun Fu1, Song Miao2, Kikuko Hotta3, Giriraj R Chandak4, Bo Xi5. 1. Department of Maternal and Child Health Care, School of Public Health, Shandong University, Jinan, People's Republic of China. 2. Shandong Medical College (Jinan), Jinan, People's Republic of China. 3. EBM Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan. 4. CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India. Electronic address: chandakgrc@ccmb.res.in. 5. Department of Maternal and Child Health Care, School of Public Health, Shandong University, Jinan, People's Republic of China. Electronic address: xibo2010@sdu.edu.cn.
Abstract
OBJECTIVES: Recent studies have suggested that fat mass and obesity-associated gene (FTO) may predispose individuals to develop hypertension. However, the results have been inconsistent. We performed a meta-analysis to investigate the relationship of FTO gene variant with risk of hypertension and influence of body mass index (BMI) on this risk. MATERIALS/ METHODS: A systematic literature search in PubMed, Embase and ISI web of science databases was performed to identify eligible published literatures. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. RESULTS: A total of seven studies comprising 57,464 hypertensive cases and 41,256 controls met the inclusion criteria and were included in the meta-analysis. The FTO gene variant(s) showed significant association with the risk of hypertension (OR=1.16, 95% CI=1.07-1.25, P<0.001) which disappeared on adjustment for BMI (OR=1.04, 95% CI=0.98-1.10, P=0.162). In addition, stratified analysis demonstrated a significant association of the FTO variant with the risk of hypertension in obese subjects (OR=1.10, 95% CI=1.01-1.19, P=0.032) but not in non-obese individuals (OR=1.00, 95% CI=0.97-1.03, P=0.832). Subgroup analysis based on ethnicity showed significant association between FTO variant and hypertension in both European (OR=1.07, 95% CI=1.01-1.14, P=0.028) and Asian populations (OR=1.37, 95% CI=1.23-1.53, P<0.001). However, the association remained significant only in Asians (OR=1.17, 95% CI=1.01-1.35, P=0.035) but not in the Europeans (OR=1.02, 95% CI=0.97-1.07, P=0.390) on adjustment for BMI. CONCLUSIONS: The present meta-analysis confirms that FTO genotype mediates obesity-related hypertension.
OBJECTIVES: Recent studies have suggested that fat mass and obesity-associated gene (FTO) may predispose individuals to develop hypertension. However, the results have been inconsistent. We performed a meta-analysis to investigate the relationship of FTO gene variant with risk of hypertension and influence of body mass index (BMI) on this risk. MATERIALS/ METHODS: A systematic literature search in PubMed, Embase and ISI web of science databases was performed to identify eligible published literatures. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. RESULTS: A total of seven studies comprising 57,464 hypertensive cases and 41,256 controls met the inclusion criteria and were included in the meta-analysis. The FTO gene variant(s) showed significant association with the risk of hypertension (OR=1.16, 95% CI=1.07-1.25, P<0.001) which disappeared on adjustment for BMI (OR=1.04, 95% CI=0.98-1.10, P=0.162). In addition, stratified analysis demonstrated a significant association of the FTO variant with the risk of hypertension in obese subjects (OR=1.10, 95% CI=1.01-1.19, P=0.032) but not in non-obese individuals (OR=1.00, 95% CI=0.97-1.03, P=0.832). Subgroup analysis based on ethnicity showed significant association between FTO variant and hypertension in both European (OR=1.07, 95% CI=1.01-1.14, P=0.028) and Asian populations (OR=1.37, 95% CI=1.23-1.53, P<0.001). However, the association remained significant only in Asians (OR=1.17, 95% CI=1.01-1.35, P=0.035) but not in the Europeans (OR=1.02, 95% CI=0.97-1.07, P=0.390) on adjustment for BMI. CONCLUSIONS: The present meta-analysis confirms that FTO genotype mediates obesity-related hypertension.
Authors: S M Heffernan; G K Stebbings; L P Kilduff; R M Erskine; S H Day; C I Morse; J S McPhee; C J Cook; B Vance; W J Ribbans; S M Raleigh; C Roberts; M A Bennett; G Wang; M Collins; Y P Pitsiladis; A G Williams Journal: BMC Genet Date: 2017-01-19 Impact factor: 2.797
Authors: Ahmet O Çağlayan; Beyhan Tüysüz; Süleyman Coşkun; Jennifer Quon; Akdes S Harmancı; Jacob F Baranoski; Burçin Baran; E Zeynep Erson-Omay; Octavian Henegariu; Shrikant M Mane; Kaya Bilgüvar; Katsuhito Yasuno; Murat Günel Journal: J Hum Genet Date: 2016-01-07 Impact factor: 3.172