Zhi-Bo Hou1, Kai-Jin Lu, Xiao-Li Wu, Cong Chen, Xin-En Huang, Hai-Tao Yin. 1. First Department of Respiratory Medicine, Nanjing Chest Hospital and Clinical Center of Nanjing Respiratory Diseases, Nanjing, China E-mail : huangxinen06@aliyun.com, baxia1108@126.com.
Abstract
PURPOSE: Lung cancer, one of the most frequently diagnosed cancers in the world, is characterized by relatively high morbidity and mortality. Berbamine (BER) has been initially reported to exert anti-proliferative effects against a series of cancers. METHODS: In this study the in vitro cytotoxicity of BER was measured by MTT assay. In vivo anti-cancer efficacy of BER was assessed in A549 xenografts. RESULTS: Cytotoxicity tests showed dose-dependent cell growth inhibition effects of BER against A549 cells. Moreover, BER significantly reduced the growth of lung cancer in a dose-dependent manner in nude mice with prolonged survival time. CONCLUSION: Therefore, BER might be in herbal medicine for cancer therapy and further efforts are needed to explore therapeutic strategies.
PURPOSE:Lung cancer, one of the most frequently diagnosed cancers in the world, is characterized by relatively high morbidity and mortality. Berbamine (BER) has been initially reported to exert anti-proliferative effects against a series of cancers. METHODS: In this study the in vitro cytotoxicity of BER was measured by MTT assay. In vivo anti-cancer efficacy of BER was assessed in A549 xenografts. RESULTS:Cytotoxicity tests showed dose-dependent cell growth inhibition effects of BER against A549 cells. Moreover, BER significantly reduced the growth of lung cancer in a dose-dependent manner in nude mice with prolonged survival time. CONCLUSION: Therefore, BER might be in herbal medicine for cancer therapy and further efforts are needed to explore therapeutic strategies.
Authors: Y Zhao; J J Lv; J Chen; X B Jin; M W Wang; Z H Su; L Y Wang; H Y Zhang Journal: Prostate Cancer Prostatic Dis Date: 2016-07-19 Impact factor: 5.554
Authors: Ana Damjanović; Branka Kolundžija; Ivana Z Matić; Ana Krivokuća; Gordana Zdunić; Katarina Šavikin; Radmila Janković; Jelena Antić Stanković; Tatjana P Stanojković Journal: Molecules Date: 2020-11-10 Impact factor: 4.411