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Literature DB >> 24641323

GABA_B receptors in the bladder and bowel: therapeutic potential for positive allosteric modulators?: Commentary on Kalinichev et al., Br J Pharmacol 171: 995-1006.

Abstract

LINKED ARTICLE: This article is a Commentary on Kalinichev M, Palea S, Haddouk H, Royer-Urios I, Guilloteau V, Lluel P, Schneider M, Saporito M and Poli S (2014). ADX71441, a novel, potent and selective positive allosteric modulator of the GABAB receptor, shows efficacy in rodent models of overactive bladder. Br J Pharmacol 171: 995-1006. doi: 10.1111/bph.12517.

Entities: Chemical

Keywords: GABAB receptor; bladder pain syndrome; colon; gastrointestinal; irritable bowel syndrome; motility; positive allosteric modulator; visceral hypersensitivity

Year: 2015 PMID： 24641323 PMCID： PMC4562517 DOI： 10.1111/bph.12617

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

14 in total

Review 1. Changes in afferent activity after spinal cord injury.

Authors: William C de Groat; Naoki Yoshimura
Journal: Neurourol Urodyn Date: 2010 Impact factor: 2.696

2. The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors.

Authors: Stephen P H Alexander; Helen E Benson; Elena Faccenda; Adam J Pawson; Joanna L Sharman; Michael Spedding; John A Peters; Anthony J Harmar
Journal: Br J Pharmacol Date: 2013-12 Impact factor: 8.739

3. Modulation of detrusor contraction strength and micturition characteristics by intrathecal baclofen in anesthetized rats.

Authors: T Watanabe; I Perkash; C E Constantinou
Journal: J Urol Date: 1997-06 Impact factor: 7.450

4. The postganglionic excitatory innervation of the mouse urinary bladder and its modulation by prejunctional GABAB receptors.

Authors: P Santicioli; C A Maggi; A Meli
Journal: J Auton Pharmacol Date: 1986-03

5. GABA(B) receptor function in the ileum and urinary bladder of wildtype and GABA(B1) subunit null mice.

Authors: G J Sanger; M L Munonyara; N Dass; H Prosser; M N Pangalos; M E Parsons
Journal: Auton Autacoid Pharmacol Date: 2002-06

6. The GABA(B) receptor agonist, baclofen, and the positive allosteric modulator, CGP7930, inhibit visceral pain-related responses to colorectal distension in rats.

Authors: Mikael Brusberg; Anna Ravnefjord; Rakel Martinsson; Håkan Larsson; Vicente Martinez; Erik Lindström
Journal: Neuropharmacology Date: 2008-09-25 Impact factor: 5.250

7. Neuronal GABA release and GABA inhibition of ACh release in guinea pig urinary bladder.

Authors: M Kusunoki; K Taniyama; C Tanaka
Journal: Am J Physiol Date: 1984-04

8. ADX71441, a novel, potent and selective positive allosteric modulator of the GABA(B) receptor, shows efficacy in rodent models of overactive bladder.

Authors: M Kalinichev; S Palea; H Haddouk; I Royer-Urios; V Guilloteau; P Lluel; M Schneider; M Saporito; S Poli
Journal: Br J Pharmacol Date: 2014-02 Impact factor: 8.739

GABA_B receptors in the bladder and bowel: therapeutic potential for positive allosteric modulators?: Commentary on Kalinichev et al., Br J Pharmacol 171: 995-1006.

Review 1. Changes in afferent activity after spinal cord injury.

2. The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors.

3. Modulation of detrusor contraction strength and micturition characteristics by intrathecal baclofen in anesthetized rats.

4. The postganglionic excitatory innervation of the mouse urinary bladder and its modulation by prejunctional GABAB receptors.

5. GABA(B) receptor function in the ileum and urinary bladder of wildtype and GABA(B1) subunit null mice.

6. The GABA(B) receptor agonist, baclofen, and the positive allosteric modulator, CGP7930, inhibit visceral pain-related responses to colorectal distension in rats.

7. Neuronal GABA release and GABA inhibition of ACh release in guinea pig urinary bladder.

8. ADX71441, a novel, potent and selective positive allosteric modulator of the GABA(B) receptor, shows efficacy in rodent models of overactive bladder.

9. A Gut Feeling about GABA: Focus on GABA(B) Receptors.

10. The Concise Guide to PHARMACOLOGY 2013/14: ligand-gated ion channels.

Review 1. Irritable bowel syndrome, the microbiota and the gut-brain axis.

Review 2. Stress-induced visceral pain: toward animal models of irritable-bowel syndrome and associated comorbidities.