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Literature DB >> 24640181

Congenic strain differences of renal malformations in ACI/Mna rats by introgression of the chromosomal region of BUF/Mna rats containing Pur1.

Mutsushi Matsuyama, Chiemi Haneda, Kazuo Kato.

Abstract

The ACI rats developed hereditary renal malformations including agenesis and hydronephrosis at moderate penetrance. During construction of a variety of congenic strains based on ACI/Mna (ACI), BUF/Mna (BUF), and WKY/NCrj (WKY) rats, we found that the renal malformations were significantly suppressed by introgression of a segment of chromosome 13 of BUF rats containing Pur1 locus. It is plausible that this region contain a modifier locus influencing development of renal malformations.

Entities: Disease Gene Species

Mesh：

Year: 2013 PMID： 24640181 PMCID： PMC4345667

Source DB: PubMed Journal: Nagoya J Med Sci ISSN： 0027-7622 Impact factor: 1.131

16 in total

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Journal: Cancer Res Date: 2005-04-01 Impact factor: 12.701

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