Literature DB >> 24639555

Transcription and processing: multilayer controls of RNA biogenesis by the Hippo pathway.

Fa-Xing Yu1, Kun-Liang Guan.   

Abstract

The Hippo pathway plays a critical role in organ size control and tumorigenesis. YAP (and also its homologue TAZ) is a transcription co-activator that mediates the biological functions of the Hippo pathway. YAP activity is inhibited upon phosphorylation by the Lats kinases (reviewed in Yu & Guan, 2013). In a recent study in Cell, Mori et al (2014) uncover a new function of YAP in global microRNA (miRNA) biogenesis by the modulation of the Microprocessor machinery. The results also suggest that this novel YAP function may contribute to cell growth control and tumorigenesis.

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Year:  2014        PMID： 24639555      PMCID： PMC4193929          DOI： 10.1002/embj.201488329

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  10 in total

1.  Cell-cell contact globally activates microRNA biogenesis.

Authors:  Hun-Way Hwang; Erik A Wentzel; Joshua T Mendell
Journal:  Proc Natl Acad Sci U S A       Date:  2009-04-09       Impact factor: 11.205

Review 2.  The Hippo pathway: regulators and regulations.

Authors:  Fa-Xing Yu; Kun-Liang Guan
Journal:  Genes Dev       Date:  2013-02-15       Impact factor: 11.361

3.  Hippo signaling regulates microprocessor and links cell-density-dependent miRNA biogenesis to cancer.

Authors:  Masaki Mori; Robinson Triboulet; Morvarid Mohseni; Karin Schlegelmilch; Kriti Shrestha; Fernando D Camargo; Richard I Gregory
Journal:  Cell       Date:  2014-02-27       Impact factor: 41.582

4.  YAP mediates crosstalk between the Hippo and PI(3)K–TOR pathways by suppressing PTEN via miR-29.

Authors:  Karen Tumaneng; Karin Schlegelmilch; Ryan C Russell; Dean Yimlamai; Harihar Basnet; Navin Mahadevan; Julien Fitamant; Nabeel Bardeesy; Fernando D Camargo; Kun-Liang Guan
Journal:  Nat Cell Biol       Date:  2012-12       Impact factor: 28.824

5.  Impaired microRNA processing enhances cellular transformation and tumorigenesis.

Authors:  Madhu S Kumar; Jun Lu; Kim L Mercer; Todd R Golub; Tyler Jacks
Journal:  Nat Genet       Date:  2007-04-01       Impact factor: 38.330

6.  MicroRNA expression profiles classify human cancers.

Authors:  Jun Lu; Gad Getz; Eric A Miska; Ezequiel Alvarez-Saavedra; Justin Lamb; David Peck; Alejandro Sweet-Cordero; Benjamin L Ebert; Raymond H Mak; Adolfo A Ferrando; James R Downing; Tyler Jacks; H Robert Horvitz; Todd R Golub
Journal:  Nature       Date:  2005-06-09       Impact factor: 49.962

7.  Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP.

Authors:  Yi Liu-Chittenden; Bo Huang; Joong Sup Shim; Qian Chen; Se-Jin Lee; Robert A Anders; Jun O Liu; Duojia Pan
Journal:  Genes Dev       Date:  2012-06-07       Impact factor: 11.361

8.  The Hippo pathway effectors TAZ/YAP regulate dicer expression and microRNA biogenesis through Let-7.

Authors:  Steven G Chaulk; Victoria J Lattanzi; Samantha E Hiemer; Richard P Fahlman; Xaralabos Varelas
Journal:  J Biol Chem       Date:  2013-12-09       Impact factor: 5.157

9.  Both TEAD-binding and WW domains are required for the growth stimulation and oncogenic transformation activity of yes-associated protein.

Authors:  Bin Zhao; Joungmok Kim; Xin Ye; Zhi-Chun Lai; Kun-Liang Guan
Journal:  Cancer Res       Date:  2009-01-13       Impact factor: 12.701

10.  Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control.

Authors:  Bin Zhao; Xiaomu Wei; Weiquan Li; Ryan S Udan; Qian Yang; Joungmok Kim; Joe Xie; Tsuneo Ikenoue; Jindan Yu; Li Li; Pan Zheng; Keqiang Ye; Arul Chinnaiyan; Georg Halder; Zhi-Chun Lai; Kun-Liang Guan
Journal:  Genes Dev       Date:  2007-11-01       Impact factor: 11.361
  10 in total
  2 in total

Review 1.  The interplay between noncoding RNA and YAP/TAZ signaling in cancers: molecular functions and mechanisms.

Authors:  Yirao Zhang; Yang Wang; Hao Ji; Jie Ding; Keming Wang
Journal:  J Exp Clin Cancer Res       Date:  2022-06-14

2.  ω-3 PUFAs ameliorate liver fibrosis and inhibit hepatic stellate cells proliferation and activation by promoting YAP/TAZ degradation.

Authors:  Kun Zhang; Yanan Chang; Zhemin Shi; Xiaohui Han; Yawei Han; Qingbin Yao; Zhimei Hu; Hongmei Cui; Lina Zheng; Tao Han; Wei Hong
Journal:  Sci Rep       Date:  2016-07-20       Impact factor: 4.379
  2 in total

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