Literature DB >> 2463926

Divalent cations modulate 5-HT3 receptor-induced currents in N1E-115 neuroblastoma cells.

J A Peters1, T G Hales, J J Lambert.   

Abstract

The influence of extracellular calcium and magnesium ion concentrations upon 5-HT3 receptor-gated membrane currents in murine N1E-115 neuroblastoma cells has been studied under voltage-clamp conditions. A decrease in the concentration of either Ca2+ or Mg2+ from their standard values of 1.0 and 2.0 mM respectively augmented both the amplitude and duration of the 5-HT-induced current, whereas elevating the concentration of either divalent cation produced the opposite effect. Such modulation did not involve a change in the reversal potential of the response.

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Year:  1988        PMID： 2463926     DOI： 10.1016/0014-2999(88)90550-x

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  24 in total

1.  Properties of 5-hydroxytryptamine3 receptor-gated currents in adult rat dorsal root ganglion neurones.

Authors:  B Robertson; S Bevan
Journal:  Br J Pharmacol       Date:  1991-01       Impact factor: 8.739

2.  Poster communications.

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3.  Functional properties of a cloned 5-hydroxytryptamine ionotropic receptor subunit: comparison with native mouse receptors.

Authors:  N Hussy; W Lukas; K A Jones
Journal:  J Physiol       Date:  1994-12-01       Impact factor: 5.182

4.  Modulation by calcineurin of 5-HT3 receptor function in NG108-15 neuroblastoma x glioma cells.

Authors:  H W Boddeke; I Meigel; P Boeijinga; J Arbuckle; R J Docherty
Journal:  Br J Pharmacol       Date:  1996-08       Impact factor: 8.739

Review 5.  Why all migraine patients should be treated with magnesium.

Authors:  Alexander Mauskop; Jasmine Varughese
Journal:  J Neural Transm (Vienna)       Date:  2012-03-18       Impact factor: 3.575

6.  Presynaptic 5-HT3 receptors evoke an excitatory response in dorsal vagal preganglionic neurones in anaesthetized rats.

Authors:  Y Wang; A G Ramage; D Jordan
Journal:  J Physiol       Date:  1998-06-15       Impact factor: 5.182

7.  Characterization of 5-HT3 receptors of N1E-115 neuroblastoma cells by use of the influx of the organic cation [14C]-guanidinium.

Authors:  H Bönisch; M Barann; J Graupner; M Göthert
Journal:  Br J Pharmacol       Date:  1993-02       Impact factor: 8.739

8.  Calcium modulation of 5-HT3 receptor binding and function.

Authors:  Andrew J Thompson; Sarah C R Lummis
Journal:  Neuropharmacology       Date:  2008-07-16       Impact factor: 5.250

9.  An electrophysiological investigation of the properties of 5-HT3 receptors of rabbit nodose ganglion neurones in culture.

Authors:  J A Peters; H M Malone; J J Lambert
Journal:  Br J Pharmacol       Date:  1993-10       Impact factor: 8.739

10.  Hydrophobic photolabeling studies identify the lipid-protein interface of the 5-HT3A receptor.

Authors:  Mitesh Sanghvi; Ayman K Hamouda; Margaret I Davis; Russell A Morton; Shouryadeep Srivastava; Akash Pandhare; Phaneendra K Duddempudi; Tina K Machu; David M Lovinger; Jonathan B Cohen; Michael P Blanton
Journal:  Biochemistry       Date:  2009-10-06       Impact factor: 3.162
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