Alicia Ann Thorp1, Bronwyn A Kingwell, Parneet Sethi, Louise Hammond, Neville Owen, David W Dunstan. 1. 1Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, AUSTRALIA; 2School of Public Health and Preventive Medicine, Monash University, Melbourne, AUSTRALIA; 3Department of Physiology, Monash University, Melbourne, AUSTRALIA; 4School of Population Health, University of Queensland, Brisbane, AUSTRALIA; 5School of Population and Global Health, Melbourne University, Melbourne, AUSTRALIA; 6School of Sport Science, Exercise and Health, University of Western Australia, Perth, AUSTRALIA; and 7School of Exercise and Nutrition Sciences, Deakin University, Melbourne, AUSTRALIA.
Abstract
PURPOSE: This study aimed to examine whether reductions in sitting time through alternating 30-min bouts of sitting and standing can reduce postprandial glucose, insulin, and triglyceride responses. METHODS:Twenty-three overweight/obese sedentary office workers (17 males and six females; mean ± SD: age, 48.2 ± 7.9 yr; body mass index, 29.6 ± 4.0 kg · m(-2)) undertook two short-term (5 d) experimental conditions in an equal, randomized (1:1) order. In a simulated office environment, participants performed typical occupational tasks for 8 h · d(-1) while in a 1) seated work posture (control condition) or 2) interchanging between a seated and standing work posture every 30 min using an electric, height-adjustable workstation (intervention condition). Fasting and postprandial blood samples after a mixed test drink were collected hourly for 4 h on days 1 and 5 of each condition to assess serum insulin, plasma glucose, and triglycerides. Dietary intake (kJ · d(-1)) and physical activity were standardized during each condition. The trial was registered with the Australian New Zealand Clinical Trials Registry (ACTRN12611000632998). RESULTS: After adjustment for time (days 1 and 5), incremental area under the analyte time curve differed significantly between conditions for plasma glucose (P = 0.007) but not for serum insulin or plasma triglycerides. Adjusted mean glucose incremental area under the analyte time curve was lowered by 11.1% after the intervention condition (6.38 mM · h(-1) (confidence interval, 5.04-7.71)) relative to the control condition (7.18 mM · h(-1) (confidence interval, 5.85-8.52)). No temporal changes (days 1 vs 5) between conditions were observed. CONCLUSIONS:Alternating standing and sitting in 30-min bouts results in modest beneficial effects on postprandial glucose responses in overweight/obese office workers.
RCT Entities:
PURPOSE: This study aimed to examine whether reductions in sitting time through alternating 30-min bouts of sitting and standing can reduce postprandial glucose, insulin, and triglyceride responses. METHODS: Twenty-three overweight/obese sedentary office workers (17 males and six females; mean ± SD: age, 48.2 ± 7.9 yr; body mass index, 29.6 ± 4.0 kg · m(-2)) undertook two short-term (5 d) experimental conditions in an equal, randomized (1:1) order. In a simulated office environment, participants performed typical occupational tasks for 8 h · d(-1) while in a 1) seated work posture (control condition) or 2) interchanging between a seated and standing work posture every 30 min using an electric, height-adjustable workstation (intervention condition). Fasting and postprandial blood samples after a mixed test drink were collected hourly for 4 h on days 1 and 5 of each condition to assess serum insulin, plasma glucose, and triglycerides. Dietary intake (kJ · d(-1)) and physical activity were standardized during each condition. The trial was registered with the Australian New Zealand Clinical Trials Registry (ACTRN12611000632998). RESULTS: After adjustment for time (days 1 and 5), incremental area under the analyte time curve differed significantly between conditions for plasma glucose (P = 0.007) but not for serum insulin or plasma triglycerides. Adjusted mean glucose incremental area under the analyte time curve was lowered by 11.1% after the intervention condition (6.38 mM · h(-1) (confidence interval, 5.04-7.71)) relative to the control condition (7.18 mM · h(-1) (confidence interval, 5.85-8.52)). No temporal changes (days 1 vs 5) between conditions were observed. CONCLUSIONS: Alternating standing and sitting in 30-min bouts results in modest beneficial effects on postprandial glucose responses in overweight/obese office workers.
Authors: Pedro B Júdice; Marc T Hamilton; Luís B Sardinha; Theodore W Zderic; Analiza M Silva Journal: Eur J Appl Physiol Date: 2016-02 Impact factor: 3.078
Authors: Sharon P Parry; Pieter Coenen; Nipun Shrestha; Peter B O'Sullivan; Christopher G Maher; Leon M Straker Journal: Cochrane Database Syst Rev Date: 2019-11-17