Sanne Visser1, Wietske Hermes2, Johannes C F Ket3, René H J Otten3, Maria G van Pampus4, Kitty W M Bloemenkamp5, Arie Franx6, Ben W Mol7, Christianne J M de Groot8. 1. Department of Obstetrics and Gynecology, Medical Center, VU University, Amsterdam, The Netherlands; Department of Obstetrics and Gynecology, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands. Electronic address: vsvisser@hotmail.com. 2. Department of Obstetrics and Gynecology, Medical Center, VU University, Amsterdam, The Netherlands; Department of Obstetrics and Gynecology, Medical Center Haaglanden, the Hague, The Netherlands. 3. Medical Library, VU University, Amsterdam, The Netherlands. 4. Department of Obstetrics and Gynecology, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands. 5. Department of Obstetrics and Gynecology, Leiden University Medical Center, Leiden, The Netherlands. 6. Department of Obstetrics and Gynecology, University Medical Center Utrecht, Utrecht, The Netherlands. 7. Department of Obstetrics and Gynecology, Amsterdam Medical Center, Amsterdam, The Netherlands. 8. Department of Obstetrics and Gynecology, Medical Center, VU University, Amsterdam, The Netherlands.
Abstract
OBJECTIVE: The aim of this study was to investigate which nonclassic cardiovascular biomarkers are associated with persistent endothelial dysfunction after pregnancy in women with a history of hypertensive pregnancy disorders compared with women with uncomplicated pregnancies. STUDY DESIGN: This was a systematic review and metaanalysis of observational studies. A search was performed in PubMed, Embase, Cochrane, and Cinahl including articles from inception to Feb. 27, 2013. Included were cohort studies and case-control studies. Cases were women with a history of hypertension in pregnancy, control subjects were women with a history of uncomplicated pregnancies. Of the 3136 found, 21 studies on 16 nonclassic cardiovascular biomarkers are described in this review; 12 studies on 5 biomarkers were included in the metaanalysis. RESULTS: Women with a history of hypertensive pregnancy disorders had a higher homocysteine level compared with women with a history of uncomplicated pregnancies (5 studies; pooled mean difference, 0.77 ng/mL; 95% confidence interval, 0.27-1.26; P < .01). For the other nonclassic cardiovascular biomarkers including markers in areas of inflammation, thrombosis, and angiogenesis, we found no significant differences. CONCLUSION: This review and metaanalysis showed that women with a history of hypertensive pregnancy disorders have higher homocysteine levels compared with women with a history of uncomplicated pregnancies. These data suggest persistent endothelial alteration after pregnancies complicated by hypertensive disorders.
OBJECTIVE: The aim of this study was to investigate which nonclassic cardiovascular biomarkers are associated with persistent endothelial dysfunction after pregnancy in women with a history of hypertensive pregnancy disorders compared with women with uncomplicated pregnancies. STUDY DESIGN: This was a systematic review and metaanalysis of observational studies. A search was performed in PubMed, Embase, Cochrane, and Cinahl including articles from inception to Feb. 27, 2013. Included were cohort studies and case-control studies. Cases were women with a history of hypertension in pregnancy, control subjects were women with a history of uncomplicated pregnancies. Of the 3136 found, 21 studies on 16 nonclassic cardiovascular biomarkers are described in this review; 12 studies on 5 biomarkers were included in the metaanalysis. RESULTS:Women with a history of hypertensive pregnancy disorders had a higher homocysteine level compared with women with a history of uncomplicated pregnancies (5 studies; pooled mean difference, 0.77 ng/mL; 95% confidence interval, 0.27-1.26; P < .01). For the other nonclassic cardiovascular biomarkers including markers in areas of inflammation, thrombosis, and angiogenesis, we found no significant differences. CONCLUSION: This review and metaanalysis showed that women with a history of hypertensive pregnancy disorders have higher homocysteine levels compared with women with a history of uncomplicated pregnancies. These data suggest persistent endothelial alteration after pregnancies complicated by hypertensive disorders.
Authors: Lauren J Tanz; Jennifer J Stuart; Stacey A Missmer; Eric B Rimm; Jennifer A Sumner; Mary A Vadnais; Janet W Rich-Edwards Journal: Pregnancy Hypertens Date: 2018-04-18 Impact factor: 2.899
Authors: Gerbrand A Zoet; Cindy Meun; Laura Benschop; Eric Boersma; Ricardo P J Budde; Bart C J M Fauser; Christianne J M de Groot; Aad van der Lugt; Angela H E M Maas; Karl G M Moons; Jeanine E Roeters van Lennep; Jolien W Roos-Hesselink; Eric A P Steegers; Bas B van Rijn; Joop S E Laven; Arie Franx; Birgitta K Velthuis Journal: BMC Womens Health Date: 2017-08-07 Impact factor: 2.809