Arthur W G Buijink1, Matthan W A Caan2, M Fiorella Contarino1, P Richard Schuurman3, Pepijn van den Munckhof3, Rob M A de Bie4, Silvia Delgado Olabarriaga5, Johannes D Speelman4, Anne-Fleur van Rootselaar6. 1. Department of Neurology and Clinical Neurophysiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Brain Imaging Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. 2. Brain Imaging Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Department of Radiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. 3. Department of Neurosurgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. 4. Department of Neurology and Clinical Neurophysiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. 5. Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. 6. Department of Neurology and Clinical Neurophysiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Brain Imaging Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. Electronic address: a.f.vanrootselaar@amc.uva.nl.
Abstract
BACKGROUND: This study set out to determine whether structural changes are present outside the thalamus after thalamotomy in patients with essential tremor (ET), specifically in the cerebellorubrothalamic tracts. We hypothesized that diffusion tensor imaging (DTI) would detect these changes. METHODS: We collected DTI scans and analyzed differences in Fractional Anisotropy (FA) and Mean Diffusivity (MD) between the left and right superior and middle cerebellar peduncle in ET patients that have undergone unilateral, left, thalamotomy and ET patients that did not undergo thalamotomy (control group). We used classical ROI-based statistics to determine whether changes are present. RESULTS: We found decreased FA and increased MD values in the right superior cerebellar peduncle leading to the left, lesioned thalamus, only in the thalamotomy group. CONCLUSIONS: Our study suggests long-term structural changes in the cerebellorubrothalamic tract after thalamotomy. This contributes to further understanding of the biological mechanism following surgical lesions in the basal ganglia.
BACKGROUND: This study set out to determine whether structural changes are present outside the thalamus after thalamotomy in patients with essential tremor (ET), specifically in the cerebellorubrothalamic tracts. We hypothesized that diffusion tensor imaging (DTI) would detect these changes. METHODS: We collected DTI scans and analyzed differences in Fractional Anisotropy (FA) and Mean Diffusivity (MD) between the left and right superior and middle cerebellar peduncle in ET patients that have undergone unilateral, left, thalamotomy and ET patients that did not undergo thalamotomy (control group). We used classical ROI-based statistics to determine whether changes are present. RESULTS: We found decreased FA and increased MD values in the right superior cerebellar peduncle leading to the left, lesioned thalamus, only in the thalamotomy group. CONCLUSIONS: Our study suggests long-term structural changes in the cerebellorubrothalamic tract after thalamotomy. This contributes to further understanding of the biological mechanism following surgical lesions in the basal ganglia.
Authors: Jose A Pineda-Pardo; Raul Martínez-Fernández; Rafael Rodríguez-Rojas; Marta Del-Alamo; Frida Hernández; Guglielmo Foffani; Michele Dileone; Jorge U Máñez-Miró; Esther De Luis-Pastor; Lydia Vela; José A Obeso Journal: Hum Brain Mapp Date: 2019-03-13 Impact factor: 5.038
Authors: Mario Stanziano; Nico Golfrè Andreasi; Giuseppe Messina; Sara Rinaldo; Sara Palermo; Mattia Verri; Greta Demichelis; Jean Paul Medina; Francesco Ghielmetti; Salvatore Bonvegna; Anna Nigri; Giulia Frazzetta; Ludovico D'Incerti; Giovanni Tringali; Francesco DiMeco; Roberto Eleopra; Maria Grazia Bruzzone Journal: Front Neurol Date: 2022-01-12 Impact factor: 4.003